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APOH apolipoprotein H (beta-2-glycoprotein I) [ Homo sapiens (human) ]

Gene ID: 350, updated on 11-Sep-2014
Official Symbol
APOHprovided by HGNC
Official Full Name
apolipoprotein H (beta-2-glycoprotein I)provided by HGNC
Primary source
HGNC:HGNC:616
See related
Ensembl:ENSG00000091583; HPRD:00728; MIM:138700; Vega:OTTHUMG00000179530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BG; B2G1; B2GP1
Summary
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
See APOH in Epigenomics, MapViewer
Location:
17q24.2
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (66212029..66229438, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (64208147..64225556, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene centrosomal protein 112kDa Neighboring gene calponin 3, acidic pseudogene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 444 Neighboring gene uncharacterized LOC101928001 Neighboring gene protein kinase C, alpha

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.
NHGRI GWA Catalog
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Binding of apolipoprotein H to HIV-1 Gag protein p18 as well as to the Gag p55 polyprotein has been demonstrated in vitro PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
lipoprotein lipase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
chylomicron IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
beta-2-glycoprotein 1
Names
beta-2-glycoprotein 1
B2GPI
apo-H
beta(2)GPI
APC inhibitor
anticardiolipin cofactor
activated protein C-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012045.1 

    Range
    5001..22410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000042.2NP_000033.2  beta-2-glycoprotein 1 precursor

    See proteins identical to NP_000033.2

    Status: REVIEWED

    Source sequence(s)
    BC026283, BG566874, BM005736
    Consensus CDS
    CCDS11663.1
    UniProtKB/Swiss-Prot
    P02749
    Related
    ENSP00000205948, OTTHUMP00000261747, ENST00000205948, OTTHUMT00000446926
    Conserved Domains (2) summary
    pfam09014
    Location:261345
    Sushi_2; Beta-2-glycoprotein-1 fifth domain
    cd00033
    Location:84137
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    66212029..66229438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    59599926..59617004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    64272419..64289828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)