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Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25086, updated on 5-Apr-2015
Official Symbol
Cyp2e1provided by RGD
Official Full Name
cytochrome P450, family 2, subfamily e, polypeptide 1provided by RGD
Primary source
RGD:2475
See related
Ensembl:ENSRNOG00000012458
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp2e
Summary
facilitates hepatocyte sensitization to tumor necrosis factor-alpha (TNF-alpha)-mediated cell death; may play a role in xenobiotic metabolism [RGD, Feb 2006]
Orthologs
See Cyp2e1 in MapViewer
Location:
1q41-q42
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213511538..213522196)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (220405975..220416727)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene olfactory receptor pseudogene 314 Neighboring gene olfactory receptor 315 Neighboring gene uncharacterized LOC103691262 Neighboring gene synaptonemal complex central element protein 1 Neighboring gene similar to transmembrane protein 49

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
FMN binding IC
Inferred by Curator
more info
PubMed 
arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
drug metabolic process ISO
Inferred from Sequence Orthology
more info
 
epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
heterocycle metabolic process IEA
Inferred from Electronic Annotation
more info
 
heterocycle metabolic process ISO
Inferred from Sequence Orthology
more info
 
monoterpenoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
monoterpenoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to ozone IEP
Inferred from Expression Pattern
more info
PubMed 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
xenobiotic metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cytochrome P450 2E1
Names
cytochrome P450 2E1
4-nitrophenol 2-hydroxylase
CYPIIE1
P450-J
P450RLM6
cytochrome P450 subfamily 2e1 (ethanol-inducible)
cytochrome P450, subfamily 2E, polypeptide 1
cytochrome P450-J
cytochrome P450RLM6
NP_113731.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031543.1NP_113731.1  cytochrome P450 2E1

    See proteins identical to NP_113731.1

    Status: PROVISIONAL

    Source sequence(s)
    J02627
    UniProtKB/Swiss-Prot
    P05182
    Related
    ENSRNOP00000016883, ENSRNOT00000016883
    Conserved Domains (1) summary
    pfam00067
    Location:33489
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    213511538..213522196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230520.1XP_006230582.1  

    Conserved Domains (1) summary
    pfam00067
    Location:98554
    p450; Cytochrome P450

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    193484404..193494772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)