Display Settings:

Format

Send to:

Choose Destination

Ppara peroxisome proliferator activated receptor alpha [ Mus musculus (house mouse) ]

Gene ID: 19013, updated on 22-Nov-2014
Official Symbol
Pparaprovided by MGI
Official Full Name
peroxisome proliferator activated receptor alphaprovided by MGI
Primary source
MGI:MGI:104740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppar; Nr1c1; AW742785; PPARalpha; PPAR-alpha; 4933429D07Rik
See Ppara in Epigenomics, MapViewer
Location:
15 E2; 15 40.42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (85735564..85806851)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene microRNA let7b Neighboring gene predicted gene, 34622 Neighboring gene cysteine rich, DPF motif domain containing 1 Neighboring gene polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity TAS
Traceable Author Statement
more info
PubMed 
receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
enamel mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
peroxisome proliferator-activated receptor alpha
Names
peroxisome proliferator-activated receptor alpha
nuclear receptor subfamily 1 group C member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113418.1NP_001106889.1  peroxisome proliferator-activated receptor alpha

    See proteins identical to NP_001106889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117784, AI118064, AK081709
    Consensus CDS
    CCDS27721.1
    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  2. NM_011144.6NP_035274.2  peroxisome proliferator-activated receptor alpha

    See proteins identical to NP_035274.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117784, AI118064, AK035676
    Consensus CDS
    CCDS27721.1
    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    85735564..85806851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520619.1XP_006520682.1  

    See proteins identical to XP_006520682.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  2. XM_006520624.1XP_006520687.1  

    Conserved Domains (2) summary
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    cl11397
    Location:201386
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. XM_006520623.1XP_006520686.1  

    See proteins identical to XP_006520686.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  4. XM_006520621.1XP_006520684.1  

    See proteins identical to XP_006520684.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  5. XM_006520620.1XP_006520683.1  

    See proteins identical to XP_006520683.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  6. XM_006520622.1XP_006520685.1  

    See proteins identical to XP_006520685.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    87868281..87938913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)