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ALDH1A1 aldehyde dehydrogenase 1 family, member A1 [ Homo sapiens (human) ]

Gene ID: 216, updated on 27-Apr-2015
Official Symbol
ALDH1A1provided by HGNC
Official Full Name
aldehyde dehydrogenase 1 family, member A1provided by HGNC
Primary source
HGNC:HGNC:402
See related
Ensembl:ENSG00000165092; HPRD:00001; MIM:100640; Vega:OTTHUMG00000020019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e
Summary
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
Orthologs
See ALDH1A1 in MapViewer
Location:
9q21.13
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (72900662..72953317, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (75515578..75653633, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene transmembrane channel-like 1 Neighboring gene ribosomal protein S27a pseudogene 15 Neighboring gene long intergenic non-protein coding RNA 1474 Neighboring gene cytochrome P450, family 1, subfamily D, polypeptide 1, pseudogene Neighboring gene uncharacterized LOC105376081

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of aldehyde dehydrogenase 1 family, member A1 (ALDH1A1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC2318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-chloroallyl aldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
aldehyde dehydrogenase (NAD) activity EXP
Inferred from Experiment
more info
 
aldehyde dehydrogenase (NAD) activity IDA
Inferred from Direct Assay
more info
PubMed 
androgen binding TAS
Traceable Author Statement
more info
PubMed 
benzaldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
retinal dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cellular aldehyde metabolic process TAS
Traceable Author Statement
more info
PubMed 
ethanol oxidation TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity TAS
Traceable Author Statement
more info
PubMed 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
retinal dehydrogenase 1
Names
retinal dehydrogenase 1
ALDH class 1
ALHDII
RALDH 1
acetaldehyde dehydrogenase 1
aldehyde dehydrogenase 1, soluble
aldehyde dehydrogenase, liver cytosolic
epididymis luminal protein 12
epididymis luminal protein 9
epididymis secretory sperm binding protein Li 53e
retinaldehyde dehydrogenase 1
NP_000680.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012249.1 RefSeqGene

    Range
    4737..57392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000689.4NP_000680.2  retinal dehydrogenase 1

    See identical proteins and their annotated locations for NP_000680.2

    Status: REVIEWED

    Source sequence(s)
    AI074764, BC001505, DC398835
    Consensus CDS
    CCDS6644.1
    UniProtKB/Swiss-Prot
    P00352
    UniProtKB/TrEMBL
    V9HW83
    Related
    ENSP00000297785, OTTHUMP00000021482, ENST00000297785, OTTHUMT00000052679
    Conserved Domains (1) summary
    cd07141
    Location:15495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    72900662..72953317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    75662616..75715255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)