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    HDAC4 histone deacetylase 4 [ Homo sapiens (human) ]

    Gene ID: 9759, updated on 29-Jun-2016
    Official Symbol
    HDAC4provided by HGNC
    Official Full Name
    histone deacetylase 4provided by HGNC
    Primary source
    HGNC:HGNC:14063
    See related
    Ensembl:ENSG00000068024 HPRD:05610; MIM:605314; Vega:OTTHUMG00000133344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
    Summary
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2q37.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (239048168..239401647, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (239969864..240323346, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene twist family bHLH transcription factor 2 Neighboring gene FLJ43879 protein Neighboring gene microRNA 4440 Neighboring gene microRNA 4441 Neighboring gene uncharacterized LOC85009 Neighboring gene microRNA 4269 Neighboring gene uncharacterized LOC101928111 Neighboring gene microRNA 2467 Neighboring gene uncharacterized LOC401040 Neighboring gene uncharacterized LOC105373966

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Chromosome 2q37 deletion syndrome
    MedGen: CN036063 GeneReviews: 2q37 Microdeletion Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2011-11-07)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated (2011-11-07)

    ClinGen Genome Curation PagePubMed

    NHGRI GWAS Catalog

    Description
    Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
    NHGRI GWA Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    NHGRI GWA Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    NHGRI GWA Catalog
    Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    reverse transcriptase gag-pol Amino acid starvation-dependent HDAC4 downregulation leads to HIV-1 transcriptional activation and RT activity production in T-lymphocytes PubMed

    Go to the HIV-1, Human Interaction Database

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
    • Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
      Endochondral Ossification, organism-specific biosystem
      Endochondral Ossification
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
      Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
    • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
    • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • Signaling events mediated by HDAC Class II, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class II, organism-specific biosystem
      Signaling events mediated by HDAC Class II
    • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class III, organism-specific biosystem
      Signaling events mediated by HDAC Class III
    • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
      Sumoylation by RanBP2 regulates transcriptional repression
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0288

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase III transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    potassium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    B cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cardiac muscle hypertrophy in response to stress TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to parathyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    osteoblast development IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of reactive oxygen species biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cardiac muscle contraction by calcium ion signaling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    response to denervation involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to interleukin-1 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    A band IEA
    Inferred from Electronic Annotation
    more info
     
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    actomyosin IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    histone deacetylase 4
    Names
    histone deacetylase A
    NP_006028.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009235.1 RefSeqGene

      Range
      5001..357780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006037.3NP_006028.2  histone deacetylase 4

      See identical proteins and their annotated locations for NP_006028.2

      Status: REVIEWED

      Source sequence(s)
      AB006626, AI199675, AI654062, BC039904, BQ576173
      Consensus CDS
      CCDS2529.1
      UniProtKB/Swiss-Prot
      P56524
      Related
      ENSP00000264606, OTTHUMP00000164483, ENST00000345617, OTTHUMT00000257174
      Conserved Domains (2) summary
      cd10162
      Location:91152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6491057
      HDAC4; Histone deacetylase 4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      239048168..239401647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512221.1XP_011510523.1  

      See identical proteins and their annotated locations for XP_011510523.1

      Conserved Domains (2) summary
      cd10162
      Location:91152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6541062
      HDAC4; Histone deacetylase 4
    2. XM_011512226.2XP_011510528.1  

      Conserved Domains (2) summary
      cd10162
      Location:67128
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6301038
      HDAC4; Histone deacetylase 4
    3. XM_006712878.3XP_006712941.1  

      See identical proteins and their annotated locations for XP_006712941.1

      Conserved Domains (2) summary
      cd10162
      Location:91152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6541062
      HDAC4; Histone deacetylase 4
    4. XM_011512222.2XP_011510524.1  

      See identical proteins and their annotated locations for XP_011510524.1

      Related
      ENSP00000440481, ENST00000543185
      Conserved Domains (2) summary
      cd10162
      Location:91152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6541062
      HDAC4; Histone deacetylase 4
    5. XM_011512223.2XP_011510525.1  

      See identical proteins and their annotated locations for XP_011510525.1

      Conserved Domains (2) summary
      cd10162
      Location:91152
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6541062
      HDAC4; Histone deacetylase 4
    6. XM_017005394.1XP_016860883.1  

    7. XM_011512219.2XP_011510521.1  

      Conserved Domains (2) summary
      cd10162
      Location:115176
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6731076
      HDAC4; Histone deacetylase 4
    8. XM_006712877.3XP_006712940.1  

      Conserved Domains (2) summary
      cd10162
      Location:115176
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6731081
      HDAC4; Histone deacetylase 4
    9. XM_011512218.2XP_011510520.1  

      Conserved Domains (2) summary
      cd10162
      Location:115176
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6781081
      HDAC4; Histone deacetylase 4
    10. XM_011512217.2XP_011510519.1  

      Conserved Domains (2) summary
      cd10162
      Location:115176
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6781086
      HDAC4; Histone deacetylase 4
    11. XM_006712879.3XP_006712942.1  

      See identical proteins and their annotated locations for XP_006712942.1

      Conserved Domains (2) summary
      cd10162
      Location:64125
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6271035
      HDAC4; Histone deacetylase 4
    12. XM_006712880.3XP_006712943.1  

      See identical proteins and their annotated locations for XP_006712943.1

      Conserved Domains (2) summary
      cd10162
      Location:64125
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6271035
      HDAC4; Histone deacetylase 4
    13. XM_011512220.2XP_011510522.1  

      Conserved Domains (2) summary
      cd10162
      Location:92153
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6551063
      HDAC4; Histone deacetylase 4
    14. XM_011512225.2XP_011510527.1  

      Conserved Domains (2) summary
      cd10162
      Location:86147
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6441052
      HDAC4; Histone deacetylase 4
    15. XM_011512224.2XP_011510526.1  

      Conserved Domains (2) summary
      cd10162
      Location:86147
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6491057
      HDAC4; Histone deacetylase 4
    16. XM_011512227.2XP_011510529.1  

      Conserved Domains (2) summary
      cd10162
      Location:43104
      ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
      cd10006
      Location:6061014
      HDAC4; Histone deacetylase 4
    17. XM_017005395.1XP_016860884.1  

    18. XM_011512230.1XP_011510532.1  

      Conserved Domains (1) summary
      cd10006
      Location:238646
      HDAC4; Histone deacetylase 4

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      239975706..240328679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)