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JAK2 Janus kinase 2 [ Homo sapiens (human) ]

Gene ID: 3717, updated on 7-Dec-2014
Official Symbol
JAK2provided by HGNC
Official Full Name
Janus kinase 2provided by HGNC
Primary source
HGNC:HGNC:6192
See related
Ensembl:ENSG00000096968; HPRD:00993; MIM:147796; Vega:OTTHUMG00000019490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JTK10; THCYT3
Summary
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
See JAK2 in Epigenomics, MapViewer
Location:
9p24
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (4985245..5129948)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (4985245..5129948)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA terminal phosphate cyclase-like 1 Neighboring gene microRNA 101-2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 41 Neighboring gene casein kinase 1, gamma 2 pseudogene 1 Neighboring gene prenyl (decaprenyl) diphosphate synthase, subunit 1 pseudogene 1 Neighboring gene MT-ND1 pseudogene 11 Neighboring gene MT-ND4 pseudogene 14 Neighboring gene MT-ND5 pseudogene 14 Neighboring gene transcription factor 3 pseudogene 1 Neighboring gene immunoglobulin heavy constant epsilon P2 (pseudogene) Neighboring gene insulin-like 6 Neighboring gene insulin-like 4 (placenta)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Budd-Chiari syndrome
MedGen: C0856761 OMIM: 600880 GeneReviews: Not available
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Familial erythrocytosis, 1
MedGen: C1851490 OMIM: 133100 GeneReviews: Not available
Compare labs
Myelofibrosis
MedGen: C0001815 OMIM: 254450 GeneReviews: Not available
Compare labs
Polycythemia vera
MedGen: C0032463 OMIM: 263300 GeneReviews: Not available
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Thrombocythemia 3
MedGen: C3281125 OMIM: 614521 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
NHGRI GWA Catalog
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
NHGRI GWA Catalog
A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.
NHGRI GWA Catalog
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
NHGRI GWA Catalog
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed

Go to the HIV-1, Human Interaction Database

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  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
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  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
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  • Cholinergic synapse, organism-specific biosystem (from KEGG)
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  • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
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  • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
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    IL27-mediated signaling events, organism-specific biosystem
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    IL4-mediated signaling events, organism-specific biosystem
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  • IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL6-mediated signaling events, organism-specific biosystem
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  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
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  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
  • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
    Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
  • Interleukin-11 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Interleukin-11 Signaling Pathway, organism-specific biosystemIL-11 is a multifunctional cytokine that belongs to the gp130 family. It was first isolated from a primate bone marrow derived cell line, PU-34 for its ability to stimulate the proliferation of a pla...
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
  • Interleukin-6 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-6 signaling, organism-specific biosystemInterleukin-6 (IL-6) is a pleiotropic cytokine with roles in processes including immune regulation, hematopoiesis, inflammation, oncogenesis, metabolic control and sleep. It is the founding member o...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
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    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
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  • Leishmaniasis, organism-specific biosystem (from KEGG)
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  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
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  • Measles, organism-specific biosystem (from KEGG)
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    Notch-mediated HES/HEY network, organism-specific biosystem
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  • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
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  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
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  • Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
    Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
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  • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
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  • Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
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  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
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  • Prolactin signaling pathway, conserved biosystem (from KEGG)
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  • RMTs methylate histone arginines, organism-specific biosystem (from REACTOME)
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  • Regulation of IFNG signaling, organism-specific biosystem (from REACTOME)
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  • S1P3 pathway, organism-specific biosystem (from Pathway Interaction Database)
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  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
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  • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by PTP1B, organism-specific biosystem
    Signaling events mediated by PTP1B
  • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
    Signaling events mediated by Stem cell factor receptor (c-Kit)
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
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  • TSH signaling pathway, organism-specific biosystem (from WikiPathways)
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  • TSLP Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TSLP Signaling Pathway, organism-specific biosystemThymic stromal lymphopoietin (TSLP) is a type I cytokine member of interleukin-2 cytokine family. TSLP signals through interleukin-7 receptor a chain (IL-7Ra) and the TSLP receptor subunit (TSLPR), h...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
    Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
acetylcholine receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
growth hormone receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
histone kinase activity (H3-Y41 specific) IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-12 receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
peptide hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 
protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
type 1 angiotensin receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway TAS
Traceable Author Statement
more info
 
STAT protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament polymerization NAS
Non-traceable Author Statement
more info
PubMed 
activation of JAK2 kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
axon regeneration IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular component movement TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
enzyme linked receptor protein signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-Y41 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
host programmed cell death induced by symbiont IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-12-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
mammary gland epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
mesoderm development TAS
Traceable Author Statement
more info
PubMed 
mineralocorticoid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of growth hormone receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein import into nucleus, translocation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tyrosine phosphorylation of Stat5 protein ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
response to antibiotic IDA
Inferred from Direct Assay
more info
PubMed 
response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-12 IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
 
tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
 
tyrosine phosphorylation of Stat1 protein IEA
Inferred from Electronic Annotation
more info
 
tyrosine phosphorylation of Stat3 protein IEA
Inferred from Electronic Annotation
more info
 
tyrosine phosphorylation of Stat5 protein IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome lumen TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tyrosine-protein kinase JAK2
Names
tyrosine-protein kinase JAK2
JAK-2
Janus kinase 2 (a protein tyrosine kinase)
NP_004963.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009904.1 

    Range
    5001..147939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_612

mRNA and Protein(s)

  1. NM_004972.3NP_004963.1  tyrosine-protein kinase JAK2

    See proteins identical to NP_004963.1

    Status: REVIEWED

    Source sequence(s)
    AF005216, AF058925, AI923337, AL158147
    Consensus CDS
    CCDS6457.1
    UniProtKB/Swiss-Prot
    O60674
    Related
    ENSP00000371067, OTTHUMP00000021024, ENST00000381652, OTTHUMT00000051609
    Conserved Domains (6) summary
    cd05078
    Location:549806
    PTK_Jak2_Jak3_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3
    cd05081
    Location:8441127
    PTKc_Jak2_Jak3_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38270
    B41; Band 4.1 homologues
    cd13333
    Location:238414
    FERM_C_JAK2; Janus kinase (JAK) 2 FERM domain C-lobe
    pfam07714
    Location:8491119
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    4985245..5129948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251455.2XP_005251512.1  

    See proteins identical to XP_005251512.1

    UniProtKB/Swiss-Prot
    O60674
    Conserved Domains (6) summary
    cd05078
    Location:549806
    PTK_Jak2_Jak3_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3
    cd05081
    Location:8441127
    PTKc_Jak2_Jak3_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases 2 and 3
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38270
    B41; Band 4.1 homologues
    cd13333
    Location:238414
    FERM_C_JAK2; Janus kinase (JAK) 2 FERM domain C-lobe
    pfam07714
    Location:8491119
    Pkinase_Tyr; Protein tyrosine kinase

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    4985470..5128355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    4940783..5083727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)