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    EZR ezrin [ Homo sapiens (human) ]

    Gene ID: 7430, updated on 26-Jul-2016
    Official Symbol
    EZRprovided by HGNC
    Official Full Name
    ezrinprovided by HGNC
    Primary source
    HGNC:HGNC:12691
    See related
    Ensembl:ENSG00000092820 HPRD:00475; MIM:123900; Vega:OTTHUMG00000015917
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CVL; CVIL; VIL2; HEL-S-105
    Summary
    The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6q25.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (158765741..158819424, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159186773..159240456, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene synaptotagmin like 3 Neighboring gene archaelysin family metallopeptidase 2 pseudogene 2 Neighboring gene microRNA 3918 Neighboring gene EZR antisense RNA 1 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 1 Neighboring gene chromosome 6 open reading frame 99

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    siRNA knockdown of EZR enhances HIV-1 replication; HIV-1 replication is restricted by EZR PubMed
    Knockdown of ezrin by shRNA results in the production of virus with decreased infectivity and the enhancement of HIV-1-induced cell-cell fusion PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Interaction of the X4-tropic protein HIV-1 gp120 with CD4 augments ezrin and moesin phosphorylation in human permissive T cells, thereby regulating ezrin-moesin activation PubMed
    env HIV-1 gp120-mediated CD4 engagement is involved in the induction of susceptibility of primary human T lymphocytes to CD95-mediated apoptosis through ezrin phosphorylation and ezrin-to-CD95 association PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 induces CD95-mediated apoptosis, CD95/ERM protein (ezrin, radixin, moesin) colocalization and stable ezrin phosphorylation PubMed
    env Ezrin and moesin are structural proteins that bind to the cellular membrane and interact with HIV-1 gp120/gp160 in CD4- and Gal-C-negative brain cells; ezrin and moesin play a role as gp120/gp160 binding proteins during the uptake of HIV PubMed
    Nef nef Knockdown of ezrin by siRNA enhances HIV-1 infectivity and inhibits HIV-1 Nef ability to increase virus infectivity, neither activity is affected by ezrin overexpression PubMed
    Pr55(Gag) gag HIV-1 Gag co-localizes with ezrin-radixin-moesin proteins at polarized HIV-1 assembly sites in human T cells PubMed
    gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
    Tat tat Expression of HIV-1 Tat downregulates the abundance of ezrin (EZR) in the nucleoli of Jurkat T-cells PubMed
    Vpr vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
    vpr HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of ezrin protein expression, indicating a role of Vpr in microfilament system assembly PubMed
    matrix gag HIV-1 MA interacts with EZR PubMed

    Go to the HIV-1, Human Interaction Database

    • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
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      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • Gastric acid secretion, organism-specific biosystem (from KEGG)
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    • L1CAM interactions, organism-specific biosystem (from REACTOME)
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    • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      LKB1 signaling events, organism-specific biosystem
      LKB1 signaling events
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
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    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
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    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
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    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
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    • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
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    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
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    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
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    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
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    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
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    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC1584, FLJ26216, DKFZp762H157

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    S100 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A regulatory subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cellular protein complex localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cAMP IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeletal anchoring at plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment of centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of endothelial barrier IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intestinal D-glucose absorption IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte cell-cell adhesion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    membrane to membrane docking IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-2 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylinositol-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cellular protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of early endosome to late endosome transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of early endosome to late endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of establishment of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to early endosome IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase A signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    NOT regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of microvillus length IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of organelle assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of organelle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sphingosine-1-phosphate signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    terminal web assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Schwann cell microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    T-tubule IEA
    Inferred from Electronic Annotation
    more info
     
    NOT colocalizes_with TCR signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    astrocyte projection IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    brush border ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell tip IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    cortical cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microspike IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    uropod IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ezrin
    Names
    cytovillin 2
    epididymis secretory protein Li 105
    p81
    villin 2 (ezrin)
    villin-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111077.1NP_001104547.1  ezrin

      See identical proteins and their annotated locations for NP_001104547.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI366687, BC013903, DA754543
      Consensus CDS
      CCDS5258.1
      UniProtKB/Swiss-Prot
      P15311
      Related
      ENSP00000356042, OTTHUMP00000017506, ENST00000367075, OTTHUMT00000042878
      Conserved Domains (6) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      pfam00769
      Location:338586
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:986
      FERM_N; FERM N-terminal domain
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      cd14473
      Location:98198
      FERM_B-lobe; FERM domain B-lobe
      cl19901
      Location:303432
      Tape_meas_lam_C; Lambda phage tail tape-measure protein (Tape_meas_lam_C)
    2. NM_003379.4NP_003370.2  ezrin

      See identical proteins and their annotated locations for NP_003370.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI366687, BC013903, DA783190
      Consensus CDS
      CCDS5258.1
      UniProtKB/Swiss-Prot
      P15311
      Related
      ENSP00000338934, OTTHUMP00000017507, ENST00000337147, OTTHUMT00000042879
      Conserved Domains (6) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      pfam00769
      Location:338586
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:986
      FERM_N; FERM N-terminal domain
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      cd14473
      Location:98198
      FERM_B-lobe; FERM domain B-lobe
      cl19901
      Location:303432
      Tape_meas_lam_C; Lambda phage tail tape-measure protein (Tape_meas_lam_C)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      158765741..158819424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536110.1XP_011534412.1  

      See identical proteins and their annotated locations for XP_011534412.1

      Conserved Domains (3) summary
      pfam00769
      Location:202450
      ERM; Ezrin/radixin/moesin family
      cd13194
      Location:64160
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      cd14473
      Location:2462
      FERM_B-lobe; FERM domain B-lobe

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      159449491..159503058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)