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Inpp4b inositol polyphosphate-4-phosphatase, type II [ Mus musculus (house mouse) ]

Gene ID: 234515, updated on 11-Aug-2014
Official Symbol
Inpp4bprovided by MGI
Official Full Name
inositol polyphosphate-4-phosphatase, type IIprovided by MGI
Primary source
MGI:2158925
See related
Ensembl:ENSMUSG00000037940; Vega:OTTMUSG00000035809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130107I17Rik
See Inpp4b in Epigenomics, MapViewer
Location:
8 C2; 8 39.02 cM
Exon count:
32
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 8 NC_000074.6 (81342342..82134060)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene coenzyme Q10 homolog B pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene predicted gene 9520 Neighboring gene interleukin 15

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol bisphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 
phosphatidylinositol trisphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 
phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
 
dephosphorylation IDA
Inferred from Direct Assay
more info
 
inositol phosphate dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
 
negative regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 
phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
 
regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 
regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cell IGI
Inferred from Genetic Interaction
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
type II inositol 3,4-bisphosphate 4-phosphatase
Names
type II inositol 3,4-bisphosphate 4-phosphatase
phosphoinositide 4-phosphatase
type II inositol-3,4-bisphosphate 4-phosphatase
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
phosphatidylinositol-3,4-bisphosphate 4-phosphatase
inositol polyphosphate 4-phosphatase type II beta isoform
NP_001019788.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024617.3NP_001019788.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 2

    See proteins identical to NP_001019788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC115778, AK139397, BC064813, DQ296611
    Consensus CDS
    CCDS22446.1
    UniProtKB/Swiss-Prot
    Q6P1Y8
    Related
    ENSMUSP00000044466, OTTMUSP00000050543, ENSMUST00000042529, OTTMUST00000091714
    Conserved Domains (1) summary
    cd04048
    Location:39158
    Blast Score: 274
    C2A_Copine; C2 domain first repeat in Copine
  2. NM_001297591.1NP_001284520.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 1

    See proteins identical to NP_001284520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK139397, AK141502, DQ296613
    Conserved Domains (1) summary
    cd04048
    Location:39175
    Blast Score: 260
    C2A_Copine; C2 domain first repeat in Copine
  3. NM_001297593.1NP_001284522.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and uses an alternate last exon compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC121136, AK141502, DQ296611, DQ296612
    Conserved Domains (1) summary
    cl14603
    Location:25114
    Blast Score: 158
    C2; C2 domain
  4. NM_001297596.1NP_001284525.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 4

    See proteins identical to NP_001284525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate last exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121136, AK141502, DQ296611
    Conserved Domains (1) summary
    cd04048
    Location:39175
    Blast Score: 260
    C2A_Copine; C2 domain first repeat in Copine

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000074.6 

    Range
    81342342..82134060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530860.1XP_006530923.1  

    Related
    ENSMUSP00000131947, OTTMUSP00000050539, ENSMUST00000169116, OTTMUST00000091710
    Conserved Domains (1) summary
    cd04048
    Location:39175
    Blast Score: 259
    C2A_Copine; C2 domain first repeat in Copine
  2. XM_006530858.1XP_006530921.1  

    See proteins identical to XP_006530921.1

    UniProtKB/TrEMBL
    E9PVM1
    Related
    ENSMUSP00000131324, OTTMUSP00000050542, ENSMUST00000172031, OTTMUST00000091713
    Conserved Domains (1) summary
    cd04048
    Location:39175
    Blast Score: 260
    C2A_Copine; C2 domain first repeat in Copine
  3. XM_006530855.1XP_006530918.1  

    See proteins identical to XP_006530918.1

    UniProtKB/TrEMBL
    E9PVM3
    Conserved Domains (1) summary
    cd04048
    Location:39175
    Blast Score: 260
    C2A_Copine; C2 domain first repeat in Copine
  4. XM_006530854.1XP_006530917.1  

    See proteins identical to XP_006530917.1

    UniProtKB/TrEMBL
    E9PVM3
    Conserved Domains (1) summary
    cd04048
    Location:39175
    Blast Score: 260
    C2A_Copine; C2 domain first repeat in Copine
  5. XM_006530859.1XP_006530922.1  

    UniProtKB/Swiss-Prot
    Q6P1Y8
    Conserved Domains (1) summary
    cd04048
    Location:39158
    Blast Score: 274
    C2A_Copine; C2 domain first repeat in Copine
  6. XM_006530861.1XP_006530924.1  

    Conserved Domains (1) summary
    cl14603
    Location:25114
    Blast Score: 158
    C2; C2 domain
  7. XM_006530856.1XP_006530919.1  

    See proteins identical to XP_006530919.1

    UniProtKB/TrEMBL
    E9PVM3
    Related
    ENSMUSP00000105478, OTTMUSP00000050540, ENSMUST00000109852, OTTMUST00000091711
    Conserved Domains (1) summary
    cd04048
    Location:39175
    Blast Score: 260
    C2A_Copine; C2 domain first repeat in Copine
  8. XM_006530857.1XP_006530920.1  

    See proteins identical to XP_006530920.1

    UniProtKB/TrEMBL
    E9PVM3
    Conserved Domains (1) summary
    cd04048
    Location:39175
    Blast Score: 260
    C2A_Copine; C2 domain first repeat in Copine
  9. XM_006530862.1XP_006530925.1  

    See proteins identical to XP_006530925.1

  10. XM_006530863.1XP_006530926.1  

    See proteins identical to XP_006530926.1

    Related
    ENSMUSP00000105477, OTTMUSP00000050545, ENSMUST00000109851, OTTMUST00000091719

Alternate Mm_Celera

Genomic

  1. AC_000030.1 

    Range
    86003317..86422617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)