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    RGS4 regulator of G-protein signaling 4 [ Homo sapiens (human) ]

    Gene ID: 5999, updated on 16-Aug-2016
    Official Symbol
    RGS4provided by HGNC
    Official Full Name
    regulator of G-protein signaling 4provided by HGNC
    Primary source
    HGNC:HGNC:10000
    See related
    Ensembl:ENSG00000117152 HPRD:03947; MIM:602516; Vega:OTTHUMG00000034417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGP4; SCZD9
    Summary
    Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1q23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (163068606..163076802)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163038396..163046592)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene uncharacterized LOC107985223 Neighboring gene uncharacterized LOC101928404 Neighboring gene regulator of G-protein signaling 5 Neighboring gene tRNA nucleotidyl transferase, CCA-adding, 1 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of regulator of G-protein signaling 4 (RGS4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (z) signalling events, organism-specific biosystemThe heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC2124, MGC60244, DKFZp761F1924

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    regulator of G-protein signaling 4
    Names
    schizophrenia disorder 9

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023312.1 RefSeqGene

      Range
      5001..13197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001102445.2NP_001095915.1  regulator of G-protein signaling 4 isoform 1

      See identical proteins and their annotated locations for NP_001095915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL583850, DC334933, DQ346664
      Consensus CDS
      CCDS44270.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000397181, OTTHUMP00000228806, ENST00000421743, OTTHUMT00000382515
      Conserved Domains (1) summary
      cd08714
      Location:160273
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
    2. NM_001113380.1NP_001106851.1  regulator of G-protein signaling 4 isoform 3

      See identical proteins and their annotated locations for NP_001106851.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL583850, EF054877
      Consensus CDS
      CCDS44272.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000356882, OTTHUMP00000032323, ENST00000367906, OTTHUMT00000083198
      Conserved Domains (1) summary
      cd08714
      Location:45158
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
    3. NM_001113381.1NP_001106852.1  regulator of G-protein signaling 4 isoform 4

      See identical proteins and their annotated locations for NP_001106852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an internal coding exon in the 3' region, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK093959, AL583850, DA660695
      Consensus CDS
      CCDS44271.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000356884, OTTHUMP00000032324, ENST00000367908, OTTHUMT00000083199
    4. NM_005613.5NP_005604.1  regulator of G-protein signaling 4 isoform 2

      See identical proteins and their annotated locations for NP_005604.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL583850, DC318279, DQ346663
      Consensus CDS
      CCDS1243.1
      UniProtKB/Swiss-Prot
      P49798
      UniProtKB/TrEMBL
      A0A024R909
      Related
      ENSP00000356885, OTTHUMP00000032322, ENST00000367909, OTTHUMT00000083197
      Conserved Domains (1) summary
      cd08714
      Location:63176
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      163068606..163076802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      164461279..164469481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)