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    SOD3 superoxide dismutase 3, extracellular [ Homo sapiens (human) ]

    Gene ID: 6649, updated on 7-Feb-2016
    Official Symbol
    SOD3provided by HGNC
    Official Full Name
    superoxide dismutase 3, extracellularprovided by HGNC
    Primary source
    HGNC:HGNC:11181
    See related
    Ensembl:ENSG00000109610; HPRD:01708; MIM:185490; Vega:OTTHUMG00000128565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EC-SOD
    Summary
    This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
    Orthologs
    See SOD3 in Epigenomics, MapViewer
    Location:
    4p15.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (24795463..24800845)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (24797085..24802467)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex subunit G pseudogene 3 Neighboring gene uncharacterized LOC105374532 Neighboring gene uncharacterized LOC105374533 Neighboring gene coiled-coil domain containing 149 Neighboring gene uncharacterized LOC102723675 Neighboring gene leucine-rich repeat LGI family member 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuate morphine and gp160-induced human monocyte apoptosis PubMed
    Tat tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
    tat Treatment of astrocytes with cell-permeable superoxide dismutase (SOD) leads to a decrease in Tat-induced ROS generation and NF-kappaB activation PubMed
    tat HIV-1 Tat reduces the expression of MnSOD in several cell types PubMed
    tat The membrane transduction efficiencies and biological activities of the SOD protein are enhanced by fusing with the Tat protein transduction domain (PTD) at both termini PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Clone Names

    • MGC20077

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    superoxide dismutase activity TAS
    Traceable Author Statement
    more info
     
    zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
     
    removal of superoxide radicals TAS
    Traceable Author Statement
    more info
    PubMed 
    response to copper ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to reactive oxygen species TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi lumen TAS
    Traceable Author Statement
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    extracellular superoxide dismutase [Cu-Zn]
    NP_003093.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012213.1 RefSeqGene

      Range
      5001..10383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003102.2NP_003093.2  extracellular superoxide dismutase [Cu-Zn] preproprotein

      See identical proteins and their annotated locations for NP_003093.2

      Status: REVIEWED

      Source sequence(s)
      AC006390, BC014418, BI757365, BM677660, DA668533
      Consensus CDS
      CCDS3430.1
      UniProtKB/Swiss-Prot
      P08294
      Related
      ENSP00000371554, OTTHUMP00000158715, ENST00000382120, OTTHUMT00000250416
      Conserved Domains (1) summary
      cd00305
      Location:69207
      Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      24795463..24800845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_427488.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      24796442..24801824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)