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    DAOA D-amino acid oxidase activator [ Homo sapiens (human) ]

    Gene ID: 267012, updated on 30-Jun-2015
    Official Symbol
    DAOAprovided by HGNC
    Official Full Name
    D-amino acid oxidase activatorprovided by HGNC
    Primary source
    HGNC:HGNC:21191
    See related
    Ensembl:ENSG00000182346; HPRD:07591; MIM:607408; Vega:OTTHUMG00000041333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LG72; SG72
    Summary
    This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]
    Orthologs
    See DAOA in Epigenomics, MapViewer
    Location:
    13q33.2; 13q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (105465867..105491034)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (106118216..106143383)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376683 Neighboring gene uncharacterized LOC105370344 Neighboring gene DAOA antisense RNA 1 Neighboring gene uncharacterized LOC105370345 Neighboring gene long intergenic non-protein coding RNA 343

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Schizophrenia
    MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    NHGRI GWA Catalog
    Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
    NHGRI GWA Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of D-amino-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    D-amino acid oxidase activator
    Names
    G72 transcript
    schizophrenia- and bipolar disorder-associated protein G72

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012694.1 RefSeqGene

      Range
      5001..30168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161812.1NP_001155284.1  D-amino acid oxidase activator isoform 2

      See identical proteins and their annotated locations for NP_001155284.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has additional segments in the 5' and 3' coding regions, as compared to variant 1, which results in a downstream AUG start codon. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AY138547, DQ386870
      Consensus CDS
      CCDS59242.1
      UniProtKB/TrEMBL
      A2T115
      UniProtKB/Swiss-Prot
      P59103
      Related
      ENSP00000469539, OTTHUMP00000269465, ENST00000595812, OTTHUMT00000461745
      Conserved Domains (1) summary
      pfam15199
      Location:57125
      DAOA; D-amino acid oxidase activator
    2. NM_001161814.1NP_001155286.1  D-amino acid oxidase activator isoform 3

      See identical proteins and their annotated locations for NP_001155286.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon and an additional segment in the 5' coding region, as compared to variant 1, which results in a downstream AUG start codon. The resulting isoform (3) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AY138547, AY170469
      Consensus CDS
      CCDS53880.1
      UniProtKB/Swiss-Prot
      P59103
      Related
      ENSP00000453831, OTTHUMP00000269458, ENST00000559369, OTTHUMT00000099036
      Conserved Domains (1) summary
      pfam15199
      Location:182
      DAOA; D-amino acid oxidase activator
    3. NM_172370.4NP_758958.3  D-amino acid oxidase activator isoform 1

      See identical proteins and their annotated locations for NP_758958.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AY138546, AY138547, BC121091
      Consensus CDS
      CCDS41905.1
      UniProtKB/Swiss-Prot
      P59103
      Related
      ENSP00000365103, OTTHUMP00000038758, ENST00000375936, OTTHUMT00000099040
      Conserved Domains (1) summary
      pfam15199
      Location:72153
      DAOA; D-amino acid oxidase activator

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

      Range
      105465867..105491034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254042.1XP_005254099.1  

      See identical proteins and their annotated locations for XP_005254099.1

      UniProtKB/TrEMBL
      A0A024RDZ4
      UniProtKB/Swiss-Prot
      P59103
      Related
      ENSP00000470244, OTTHUMP00000269459, ENST00000473269, OTTHUMT00000099039
      Conserved Domains (1) summary
      pfam15199
      Location:72126
      DAOA; D-amino acid oxidase activator

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      106086376..106111543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)