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MUTYH mutY homolog [ Homo sapiens (human) ]

Gene ID: 4595, updated on 24-Jul-2014
Official Symbol
MUTYHprovided by HGNC
Official Full Name
mutY homologprovided by HGNC
Primary source
HGNC:7527
Locus tag
RP4-534D1.2
See related
Ensembl:ENSG00000132781; HPRD:05380; MIM:604933; Vega:OTTHUMG00000007682
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYH
Summary
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
See MUTYH in Epigenomics, MapViewer
Location:
1p34.1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (45329242..45340470, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45794914..45806142, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1144 Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like Neighboring gene target of EGR1, member 1 (nuclear) Neighboring gene testis-specific kinase 2 Neighboring gene coiled-coil domain containing 163, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MUTYH that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
MYH-associated polyposis
MedGen: C1837991 OMIM: 608456 GeneReviews: MUTYH-Associated Polyposis
Compare labs
Neoplasm of stomach
MedGen: C0038356 OMIM: 613659 GeneReviews: Not available
Compare labs
Pilomatrixoma
MedGen: C0206711 OMIM: 132600 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC4416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
NOT MutLalpha complex binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT MutLbeta complex binding IDA
Inferred from Direct Assay
more info
PubMed 
MutSalpha complex binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT MutSbeta complex binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair TAS
Traceable Author Statement
more info
 
base-excision repair TAS
Traceable Author Statement
more info
 
base-excision repair, AP site formation TAS
Traceable Author Statement
more info
 
depurination TAS
Traceable Author Statement
more info
 
mismatch repair TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
A/G-specific adenine DNA glycosylase
Names
A/G-specific adenine DNA glycosylase
NP_001041636.1
NP_001041637.1
NP_001041638.1
NP_001041639.1
NP_001121897.1
NP_036354.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008189.1 

    Range
    5001..16229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_220

mRNA and Protein(s)

  1. NM_001048171.1NP_001041636.1  A/G-specific adenine DNA glycosylase isoform 2

    See proteins identical to NP_001041636.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha3), also known as type 1, uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. This difference results in a protein (isoform 2) that is shorter than isoform 5. Isoform 2 has been shown to localize to mitochondria.
    Source sequence(s)
    BC003178, BM926983
    Consensus CDS
    CCDS41320.1
    UniProtKB/TrEMBL
    E5KP27
    UniProtKB/Swiss-Prot
    Q9UIF7
    Related
    ENSP00000361187, OTTHUMP00000009096, ENST00000372115, OTTHUMT00000020528
    Conserved Domains (4) summary
    smart00525
    Location:275295
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:78480
    Blast Score: 939
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:114272
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:354483
    Blast Score: 296
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  2. NM_001048172.1NP_001041637.1  A/G-specific adenine DNA glycosylase isoform 3

    See proteins identical to NP_001041637.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma2) contains a distinct 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. These differences cause translation initiation at a downstream start codon and result in a protein (isoform 3) that is shorter than isoform 5.
    Source sequence(s)
    AB032927, CN413115
    Consensus CDS
    CCDS41321.1
    UniProtKB/TrEMBL
    E5KP28
    UniProtKB/Swiss-Prot
    Q9UIF7
    Related
    ENSP00000346354, OTTHUMP00000009101, ENST00000354383, OTTHUMT00000020534
    Conserved Domains (4) summary
    smart00525
    Location:262282
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:65467
    Blast Score: 940
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:101259
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:341470
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  3. NM_001048173.1NP_001041638.1  A/G-specific adenine DNA glycosylase isoform 4

    See proteins identical to NP_001041638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma3) contains a distinct 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. These differences cause translation initiation at a downstream start codon and result in a protein (isoform 4) that is shorter than isoform 5. Variants beta3, gamma3 and beta5 encode the same isoform 4, which has been shown to localize to the nucleus.
    Source sequence(s)
    AB032928, CN413115
    Consensus CDS
    CCDS41322.1
    UniProtKB/Swiss-Prot
    Q9UIF7
    Related
    ENSP00000347685, OTTHUMP00000009102, ENST00000355498, OTTHUMT00000020535
    Conserved Domains (4) summary
    smart00525
    Location:261281
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:64466
    Blast Score: 941
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:100258
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:340469
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  4. NM_001048174.1NP_001041639.1  A/G-specific adenine DNA glycosylase isoform 4

    See proteins identical to NP_001041639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta3), also known as type 2, contains a distinct 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. These differences cause translation initiation at a downstream start codon and result in a protein (isoform 4) that is shorter than isoform 5. Variants beta3, gamma3 and beta5 encode the same isoform 4, which has been shown to localize to the nucleus.
    Source sequence(s)
    AB032925, AL560568
    Consensus CDS
    CCDS41322.1
    UniProtKB/Swiss-Prot
    Q9UIF7
    Related
    ENSP00000407590, OTTHUMP00000009099, ENST00000456914, OTTHUMT00000020532
    Conserved Domains (4) summary
    smart00525
    Location:261281
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:64466
    Blast Score: 941
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:100258
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:340469
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  5. NM_001128425.1NP_001121897.1  A/G-specific adenine DNA glycosylase isoform 5

    See proteins identical to NP_001121897.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AB032920, AL359540, BM926983
    UniProtKB/TrEMBL
    E5KP25
    UniProtKB/Swiss-Prot
    Q9UIF7
    Related
    ENSP00000408176, ENST00000450313
    Conserved Domains (4) summary
    smart00525
    Location:289309
    Blast Score: 95
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:92494
    Blast Score: 940
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:128286
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:368497
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  6. NM_001293190.1NP_001280119.1  A/G-specific adenine DNA glycosylase isoform 6

    See proteins identical to NP_001280119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha2) uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. The resulting isoform (6) lacks an internal segment, compared to isoform 5.
    Source sequence(s)
    AB032921, BM926983
    Conserved Domains (4) summary
    smart00525
    Location:276296
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:79481
    Blast Score: 939
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:115273
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:355484
    Blast Score: 296
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  7. NM_001293191.1NP_001280120.1  A/G-specific adenine DNA glycosylase isoform 7

    See proteins identical to NP_001280120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta1) contains a distinct 5' UTR, lacks a portion of the 5' coding region and also uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. The resulting isoform (7) has a shorter N-terminus and lacks an internal 3aa segment, compared to isoform 5.
    Source sequence(s)
    AB032924, AL560568
    Conserved Domains (4) summary
    smart00525
    Location:272292
    Blast Score: 95
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:75477
    Blast Score: 941
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:111269
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:351480
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  8. NM_001293192.1NP_001280121.1  A/G-specific adenine DNA glycosylase isoform 8

    See proteins identical to NP_001280121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha4) uses an alternate splice site in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant alpha5. The resulting isoform (8) has a shorter N-terminus, compared to isoform 5. Variants alpha4 and gamma4 encode the same isoform 8.
    Source sequence(s)
    AB032923, BM926983
    Conserved Domains (4) summary
    TIGR01084
    Location:3305
    Blast Score: 710
    mutY; A/G-specific adenine glycosylase
    smart00525
    Location:169189
    Blast Score: 95
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    cd00056
    Location:8166
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:248377
    Blast Score: 298
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  9. NM_001293195.1NP_001280124.1  A/G-specific adenine DNA glycosylase isoform 4

    See proteins identical to NP_001280124.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta5) contains a distinct 5' UTR, lacks a portion of the 5' coding region and also uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. The resulting isoform (4) has a shorter N-terminus and lacks an internal segment, compared to isoform 5. Variants beta3, gamma3 and beta5 encode the same isoform 4, which has been shown to localize to the nucleus.
    Source sequence(s)
    AB032926, AL560568
    Conserved Domains (4) summary
    smart00525
    Location:261281
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:64466
    Blast Score: 941
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:100258
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:340469
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  10. NM_001293196.1NP_001280125.1  A/G-specific adenine DNA glycosylase isoform 8

    See proteins identical to NP_001280125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma4) contains a distinct 5' UTR, and uses an alternate splice site in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant alpha5. The resulting isoform (8) has a shorter N-terminus, compared to isoform 5. Variants alpha4 and gamma4 encode the same isoform 8.
    Source sequence(s)
    AB032929, BI818560, HY094590
    Conserved Domains (4) summary
    TIGR01084
    Location:3305
    Blast Score: 710
    mutY; A/G-specific adenine glycosylase
    smart00525
    Location:169189
    Blast Score: 95
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    cd00056
    Location:8166
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:248377
    Blast Score: 298
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  11. NM_012222.2NP_036354.1  A/G-specific adenine DNA glycosylase isoform 1

    See proteins identical to NP_036354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha1) uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha5. This difference results in a protein (isoform 1) that is shorter than isoform 5.
    Source sequence(s)
    AB032920, BM926983
    Consensus CDS
    CCDS520.1
    UniProtKB/TrEMBL
    E5KP26
    UniProtKB/Swiss-Prot
    Q9UIF7
    Related
    ENSP00000361170, OTTHUMP00000009097, ENST00000372098, OTTHUMT00000020529
    Conserved Domains (4) summary
    smart00525
    Location:286306
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:89491
    Blast Score: 940
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:125283
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:365494
    Blast Score: 296
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    45329242..45340470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270884.2XP_005270941.1  

    UniProtKB/TrEMBL
    D3DPZ6
    UniProtKB/Swiss-Prot
    Q9UIF7
    Conserved Domains (4) summary
    TIGR01084
    Location:3305
    Blast Score: 710
    mutY; A/G-specific adenine glycosylase
    smart00525
    Location:169189
    Blast Score: 95
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    cd00056
    Location:8166
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:248377
    Blast Score: 298
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  2. XM_005270880.2XP_005270937.1  

    UniProtKB/Swiss-Prot
    Q9UIF7
    Related
    ENSP00000361182, OTTHUMP00000009103
    Conserved Domains (4) summary
    smart00525
    Location:276296
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:79481
    Blast Score: 939
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:115273
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:355484
    Blast Score: 296
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  3. XM_006710652.1XP_006710715.1  

    See proteins identical to XP_006710715.1

    Conserved Domains (4) summary
    smart00525
    Location:146166
    Blast Score: 94
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:10351
    Blast Score: 710
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:14143
    Blast Score: 315
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:225354
    Blast Score: 295
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  4. XM_006710650.1XP_006710713.1  

    See proteins identical to XP_006710713.1

    Conserved Domains (4) summary
    smart00525
    Location:146166
    Blast Score: 94
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:10351
    Blast Score: 710
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:14143
    Blast Score: 315
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:225354
    Blast Score: 295
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  5. XM_005270885.1XP_005270942.1  

    UniProtKB/TrEMBL
    D3DPZ6
    UniProtKB/Swiss-Prot
    Q9UIF7
    Conserved Domains (4) summary
    TIGR01084
    Location:3305
    Blast Score: 710
    mutY; A/G-specific adenine glycosylase
    smart00525
    Location:169189
    Blast Score: 95
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    cd00056
    Location:8166
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:248377
    Blast Score: 298
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  6. XM_006710651.1XP_006710714.1  

    See proteins identical to XP_006710714.1

    Conserved Domains (4) summary
    smart00525
    Location:146166
    Blast Score: 94
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:10351
    Blast Score: 710
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:14143
    Blast Score: 315
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:225354
    Blast Score: 295
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  7. XM_006710649.1XP_006710712.1  

    UniProtKB/Swiss-Prot
    Q9UIF7
    Conserved Domains (4) summary
    smart00525
    Location:261281
    Blast Score: 96
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:64466
    Blast Score: 941
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:100258
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:340469
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  8. XM_005270881.2XP_005270938.1  

    UniProtKB/Swiss-Prot
    Q9UIF7
    Related
    ENSP00000409718, OTTHUMP00000009100
    Conserved Domains (4) summary
    smart00525
    Location:272292
    Blast Score: 95
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:75477
    Blast Score: 941
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:111269
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:351480
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
  9. XM_006710648.1XP_006710711.1  

    See proteins identical to XP_006710711.1

    UniProtKB/Swiss-Prot
    Q9UIF7
    Conserved Domains (4) summary
    smart00525
    Location:272292
    Blast Score: 95
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    COG1194
    Location:75477
    Blast Score: 941
    MutY; A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
    cd00056
    Location:111269
    Blast Score: 405
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    cd03431
    Location:351480
    Blast Score: 297
    DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    43906571..43917689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    45911718..45922945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)