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SIRT7 sirtuin 7 [ Homo sapiens (human) ]

Gene ID: 51547, updated on 7-Dec-2014
Official Symbol
SIRT7provided by HGNC
Official Full Name
sirtuin 7provided by HGNC
Primary source
HGNC:HGNC:14935
See related
Ensembl:ENSG00000187531; HPRD:12094; MIM:606212; Vega:OTTHUMG00000177957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L7
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
See SIRT7 in Epigenomics, MapViewer
Location:
17q25
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (81911939..81918182, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79869815..79876058, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G Neighboring gene MAFG antisense RNA 1 (head to head)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126840, MGC126842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K18 specific) IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone H3 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription on exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus organizer region IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent protein deacetylase sirtuin-7
sirtuin type 7
SIR2-like protein 7
sir2-related protein type 7
regulatory protein SIR2 homolog 7
NAD-dependent deacetylase sirtuin-7
silent mating type information regulation 2, S.cerevisiae, homolog 7
NP_057622.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016538.2NP_057622.1  NAD-dependent protein deacetylase sirtuin-7

    See proteins identical to NP_057622.1

    Status: REVIEWED

    Source sequence(s)
    BC017305, BC101791, BQ890203, CD579273
    Consensus CDS
    CCDS11792.1
    UniProtKB/Swiss-Prot
    Q9NRC8
    Related
    ENSP00000329466, OTTHUMP00000258199, ENST00000328666, OTTHUMT00000439961
    Conserved Domains (2) summary
    pfam00901
    Location:22160
    Orbi_VP5; Orbivirus outer capsid protein VP5
    cd01410
    Location:100314
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    81911939..81918182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722283.1XP_006722346.1  

    Conserved Domains (1) summary
    cl00195
    Location:78321
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. XM_005256376.2XP_005256433.2  

    Conserved Domains (2) summary
    pfam00901
    Location:22160
    Orbi_VP5; Orbivirus outer capsid protein VP5
    cd01410
    Location:100356
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
  3. XM_006722284.1XP_006722347.1  

    Conserved Domains (1) summary
    cd01410
    Location:31232
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RNA

  1. XR_430032.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    79956019..79962262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    75271436..75277679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)