Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    NRG1 neuregulin 1 [ Homo sapiens (human) ]

    Gene ID: 3084, updated on 22-Jul-2016
    Official Symbol
    NRG1provided by HGNC
    Official Full Name
    neuregulin 1provided by HGNC
    Primary source
    HGNC:HGNC:7997
    See related
    Ensembl:ENSG00000157168 HPRD:00802; MIM:142445; Vega:OTTHUMG00000163918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2
    Summary
    The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
    Orthologs
    Location:
    8p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (31639222..32771716)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (31496820..32622558)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379360 Neighboring gene RNA, 5S ribosomal pseudogene 261 Neighboring gene uncharacterized LOC107986936 Neighboring gene NRG1 intronic transcript 1 Neighboring gene RNA, 5S ribosomal pseudogene 262 Neighboring gene uncharacterized LOC105379361 Neighboring gene NRG1 intronic transcript 3 Neighboring gene uncharacterized LOC105379362 Neighboring gene RNA, U6 small nuclear 663, pseudogene Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 pseudogene 6

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Schizophrenia 6
    MedGen: C1864275 OMIM: 603013 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies potential susceptibility Loci for hirschsprung disease.
    NHGRI GWA Catalog
    A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
    NHGRI GWA Catalog
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    NHGRI GWA Catalog
    Discovery of common variants associated with low TSH levels and thyroid cancer risk.
    NHGRI GWA Catalog
    Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
    NHGRI GWA Catalog
    Genetics of coronary artery calcification among African Americans, a meta-analysis.
    NHGRI GWA Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    NHGRI GWA Catalog
    Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
    NHGRI GWA Catalog
    Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
    NHGRI GWA Catalog
    Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.
    NHGRI GWA Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    NHGRI GWA Catalog
    Genome-wide association with bone mass and geometry in the Framingham Heart Study.
    NHGRI GWA Catalog
    • ARMS-mediated activation, organism-specific biosystem (from REACTOME)
      ARMS-mediated activation, organism-specific biosystemARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
      Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
    • Constitutive Signaling by Aberrant PI3K in Cancer, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by Aberrant PI3K in Cancer, organism-specific biosystemSignaling by PI3K/AKT is frequently constitutively activated in cancer via gain-of-function mutations in one of the two PI3K subunits - PI3KCA (encoding the catalytic subunit p110alpha) or PIK3R1 (en...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • DAP12 interactions, organism-specific biosystem (from REACTOME)
      DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
    • DAP12 signaling, organism-specific biosystem (from REACTOME)
      DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Downregulation of ERBB2:ERBB3 signaling, organism-specific biosystem (from REACTOME)
      Downregulation of ERBB2:ERBB3 signaling, organism-specific biosystemLevel of plasma membrane ERBB3 is regulated by E3 ubiquitin ligase RNF41 (also known as NRDP1), which binds and ubiquitinates both inactive and activated ERBB3, targeting it for degradation (Cao et a...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • Downstream signaling of activated FGFR1, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR1, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • Downstream signaling of activated FGFR2, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR2, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • Downstream signaling of activated FGFR3, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR3, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • Downstream signaling of activated FGFR4, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR4, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • ERBB2 Activates PTK6 Signaling, organism-specific biosystem (from REACTOME)
      ERBB2 Activates PTK6 Signaling, organism-specific biosystemPTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). Howev...
    • ERBB2 Regulates Cell Motility, organism-specific biosystem (from REACTOME)
      ERBB2 Regulates Cell Motility, organism-specific biosystemActivated ERBB2 heterodimers regulate cell motility through association with MEMO1. MEMO1 retains activated RHOA GTPase and its associated protein DIAPH1 at the plasma membrane, thus linking ERBB2 ac...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
      FCERI mediated MAPK activation, organism-specific biosystemFormation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as th...
    • FRS-mediated FGFR1 signaling, organism-specific biosystem (from REACTOME)
      FRS-mediated FGFR1 signaling, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to ...
    • FRS-mediated FGFR2 signaling, organism-specific biosystem (from REACTOME)
      FRS-mediated FGFR2 signaling, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to ...
    • FRS-mediated FGFR3 signaling, organism-specific biosystem (from REACTOME)
      FRS-mediated FGFR3 signaling, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to ...
    • FRS-mediated FGFR4 signaling, organism-specific biosystem (from REACTOME)
      FRS-mediated FGFR4 signaling, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to ...
    • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
      Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
    • Frs2-mediated activation, organism-specific biosystem (from REACTOME)
      Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • GRB2 events in EGFR signaling, organism-specific biosystem (from REACTOME)
      GRB2 events in EGFR signaling, organism-specific biosystemAutophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through i...
    • GRB2 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      GRB2 events in ERBB2 signaling, organism-specific biosystemERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. ...
    • GRB7 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      GRB7 events in ERBB2 signaling, organism-specific biosystemHeterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262), but the exact downstream signaling of thi...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Glypican 1 network, organism-specific biosystem (from Pathway Interaction Database)
      Glypican 1 network, organism-specific biosystem
      Glypican 1 network
    • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
      IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
      IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
      Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
      MAPK1/MAPK3 signaling, organism-specific biosystemThe extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote diff...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
      NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Negative regulation of the PI3K/AKT network, organism-specific biosystem (from REACTOME)
      Negative regulation of the PI3K/AKT network, organism-specific biosystemThe PI3K/AKT network is negatively regulated by phosphatases that dephosphorylate PIP3, thus hampering AKT activation.
    • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
    • PI-3K cascade:FGFR1, organism-specific biosystem (from REACTOME)
      PI-3K cascade:FGFR1, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI-3K cascade:FGFR2, organism-specific biosystem (from REACTOME)
      PI-3K cascade:FGFR2, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI-3K cascade:FGFR3, organism-specific biosystem (from REACTOME)
      PI-3K cascade:FGFR3, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI-3K cascade:FGFR4, organism-specific biosystem (from REACTOME)
      PI-3K cascade:FGFR4, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
    • PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
      PI3K/AKT Signaling in Cancer, organism-specific biosystemClass IA PI3K is a heterodimer of a p85 regulatory subunit (encoded by PIK3R1, PIK3R2 or PIK3R3) and a p110 catalytic subunit (encoded by PIK3CA, PIK3CB or PIK3CD). In the absence of activating signa...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, organism-specific biosystem (from REACTOME)
      PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, organism-specific biosystemPhosphatidylinositol-5-phosphate (PI5P) may modulate PI3K/AKT signaling in several ways. PI5P is used as a substrate for production of phosphatidylinositol-4,5-bisphosphate, PI(4,5)P2 (Rameh et al. 1...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimula...
    • Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
      Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
    • RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
      RAF/MAP kinase cascade, organism-specific biosystemThe RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to growth factors, hormones and cytokines, among others. Bin...
    • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
      Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
    • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
    • SHC1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in ERBB2 signaling, organism-specific biosystemAll ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphory...
    • SHC1 events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in ERBB4 signaling, organism-specific biosystemAll splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound t...
    • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
      SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
      Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
      Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by PTK6, organism-specific biosystem (from REACTOME)
      Signaling by PTK6, organism-specific biosystemPTK6 (BRK) is an oncogenic non-receptor tyrosine kinase that functions downstream of ERBB2 (HER2) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et ...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • Signalling to RAS, organism-specific biosystem (from REACTOME)
      Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ErbB-2 class receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    ErbB-3 class receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ras guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    chemorepellent activity IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    growth factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
    Traceable Author Statement
    more info
     
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    receptor tyrosine kinase binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription cofactor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    ERBB signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ERBB signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ERBB2 signaling pathway TAS
    Traceable Author Statement
    more info
     
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of protein kinase B activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac conduction system development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cardiac muscle cell myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell communication TAS
    Traceable Author Statement
    more info
    PubMed 
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    chemorepulsion involved in interneuron migration from the subpallium to the cortex IEA
    Inferred from Electronic Annotation
    more info
     
    embryo development IEA
    Inferred from Electronic Annotation
    more info
     
    endocardial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glial cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    glucose transport IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland development TAS
    Traceable Author Statement
    more info
    PubMed 
    myelination IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    neural crest cell development TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter receptor metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peripheral nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of striated muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell motility TAS
    Traceable Author Statement
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling TAS
    Traceable Author Statement
    more info
     
    regulation of protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein homodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    startle response IEA
    Inferred from Electronic Annotation
    more info
     
    synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular trabecula myocardium morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    wound healing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    pro-neuregulin-1, membrane-bound isoform
    Names
    acetylcholine receptor-inducing activity
    glial growth factor 2
    heregulin, alpha (45kD, ERBB2 p185-activator)
    neu differentiation factor
    pro-NRG1
    sensory and motor neuron derived factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012005.1 RefSeqGene

      Range
      5001..1108504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001159995.2NP_001153467.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-beta1c), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks an in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1c, also known as type IV fetal C beta 1a or fetal b IV-beta 1a) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, CA429204, DA805080, EF517297, GQ983557, M94166
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      A6MW56, E3SFM9
      Conserved Domains (4) summary
      pfam02158
      Location:202597
      Neuregulin; Neuregulin family
      cd05895
      Location:32106
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:22108
      IG_like; Immunoglobulin like
      cd00054
      Location:152184
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. NM_001159996.2NP_001153468.1  pro-neuregulin-1, membrane-bound isoform isoform ndf43c

      See identical proteins and their annotated locations for NP_001153468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (ndf43c), which uses the type VI promoter, lacks multiple 5' exons but contains an alternate 5' terminal exon, and it also lacks two in-frame exons in the central coding region and includes an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43c, also known as ndf43) has distinct N- and C-termini, lacks an internal segment, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, AK293240, BC144446, CA429204, CN603661, DA805080, DC425692
      Consensus CDS
      CCDS75727.1
      UniProtKB/TrEMBL
      B7Z1D7, F6RJN6
      Related
      ENSP00000439276, ENST00000539990
      Conserved Domains (2) summary
      pfam02158
      Location:81270
      Neuregulin; Neuregulin family
      cd00054
      Location:3668
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    3. NM_001159999.2NP_001153471.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-beta1b), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1b, also known as type IV fetal B beta 1a) has a distinct N-terminus and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, CA429204, CN603652, DA805080, EF517296, GQ983557, M94165, U02328
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      A6MW55, E3SFM9
      Conserved Domains (4) summary
      pfam02158
      Location:219614
      Neuregulin; Neuregulin family
      cd05895
      Location:32106
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:22108
      IG_like; Immunoglobulin like
      cd00054
      Location:169201
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    4. NM_001160001.2NP_001153473.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-beta1d), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks two in-frame exons in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1d, also known as IV-beta 1a or type IV fetal A beta 1a) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, CA429204, CN603654, DA805080, EF372273, GQ983557, M94165
      Consensus CDS
      CCDS55218.1
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      E3SFM9
      Related
      ENSP00000429582, OTTHUMP00000225477, ENST00000519301, OTTHUMT00000376580
      Conserved Domains (4) summary
      pfam02158
      Location:185580
      Neuregulin; Neuregulin family
      cd05895
      Location:32106
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:22108
      IG_like; Immunoglobulin like
      cd00054
      Location:135167
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    5. NM_001160002.1NP_001153474.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-gamma2), which uses the type I promoter, lacks an internal in-frame exon and multiple 3' exons, but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma2, also known as gamma protein isoform 1) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC083977, AC103675, EU363508
      UniProtKB/TrEMBL
      B0FYA7
      Conserved Domains (2) summary
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cl11960
      Location:53127
      Ig; Immunoglobulin domain
    6. NM_001160004.2NP_001153476.1  pro-neuregulin-1, membrane-bound isoform isoform ndf43b

      See identical proteins and their annotated locations for NP_001153476.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (ndf43b), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, and contains an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43b, also known as ndf43-beta2) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC083977, AC113209, BC144446, CA429204, DA805080, EU363510
      UniProtKB/TrEMBL
      B0FYA9
      Conserved Domains (4) summary
      pfam02158
      Location:232421
      Neuregulin; Neuregulin family
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
    7. NM_001160005.1NP_001153477.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3b

      See identical proteins and their annotated locations for NP_001153477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-beta3b), which uses the type I promoter, lacks two internal in-frame exons and multiple 3' exons, but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta3b, also known as HRG-beta 3 protein isoform) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC083977, EU359055, M94168
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      B0FWZ3
      Conserved Domains (2) summary
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cl11960
      Location:53127
      Ig; Immunoglobulin domain
    8. NM_001160007.1NP_001153479.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-gamma3), which uses the type I promoter, lacks two internal in-frame exons and multiple 3' exons, but contains an alternate 3' terminal exon that results in an early stop codon and an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma3, also known as gamma protein isoform 2) lacks an internal segment and is shorter at the C-terminus, compared to isoform HRG-beta1.
      Source sequence(s)
      AC083977, AC103675, EU363509
      UniProtKB/TrEMBL
      B0FYA8
      Conserved Domains (2) summary
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cl11960
      Location:53127
      Ig; Immunoglobulin domain
    9. NM_001160008.1NP_001153480.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-beta2b), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, and it also contains alternate 3' exon structure resulting an in early stop codon and alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta2b) lacks an internal segment and is shorter at the C-terminus, compared to isoform HRG-beta1.
      Source sequence(s)
      AK097005, AK298132, BC006492, BQ018711
      Consensus CDS
      CCDS55219.1
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      Q6PK61
      Related
      ENSP00000430120, OTTHUMP00000225419, ENST00000523079, OTTHUMT00000376466
      Conserved Domains (4) summary
      pfam02158
      Location:232420
      Neuregulin; Neuregulin family
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
    10. NM_001322197.1NP_001309126.1  pro-neuregulin-1, membrane-bound isoform isoform VI-1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (VI-1), which uses the type VI promoter, lacks multiple 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks an in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (VI-1) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, AK293270, CA429204, CN603661
      UniProtKB/TrEMBL
      B7Z1E3
      Conserved Domains (2) summary
      pfam02158
      Location:78473
      Neuregulin; Neuregulin family
      cd00054
      Location:3668
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    11. NM_001322201.1NP_001309130.1  pro-neuregulin-1, membrane-bound isoform isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (fetal-a-IV-1), which uses the type IV promoter, contains an alternate 5' terminal exon and lacks three internal exons, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant HRG-beta1. The resulting isoform (a) is shorter at the N-terminus, compared to isoform HRG-beta1. Both variants fetal-a-IV-1 and fetal-c-IV-2 encode isoform a.
      Source sequence(s)
      AC083977, AC103675, AC113209, CA429204, EF372275, GQ983557
      UniProtKB/TrEMBL
      A5YAK6, E3SFM9
      Conserved Domains (1) summary
      pfam02158
      Location:1372
      Neuregulin; Neuregulin family
    12. NM_001322202.1NP_001309131.1  pro-neuregulin-1, membrane-bound isoform isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (fetal-c-IV-2), which uses the type IV promoter, contains an alternate 5' terminal exon and lacks four internal exons, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The resulting isoform (a) is shorter at the N-terminus, compared to isoform HRG-beta1. Both variants fetal-a-IV-1 and fetal-c-IV-2 encode isoform a.
      Source sequence(s)
      AC103675, AC113209, CA429204, EF372277, GQ983557
      UniProtKB/TrEMBL
      A5YAK8, E3SFM9
      Conserved Domains (1) summary
      pfam02158
      Location:1372
      Neuregulin; Neuregulin family
    13. NM_001322205.1NP_001309134.1  pro-neuregulin-1, membrane-bound isoform isoform NRG-III-beta1a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (NRG-III-beta1a), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant HRG-beta1. The resulting isoform (NRG-III-beta1a, also known as nARIAbeta1a or CRD-NRGbeta1a) has a distinct N-terminus and is longer than isoform HRG-beta1.
      Source sequence(s)
      AC103675, AC113209, AK289927, CA429204, EF517295
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      A6MW54
      Conserved Domains (2) summary
      pfam02158
      Location:295690
      Neuregulin; Neuregulin family
      PHA02887
      Location:236279
      PHA02887; EGF-like protein; Provisional
    14. NM_001322206.1NP_001309135.1  pro-neuregulin-1, membrane-bound isoform isoform III-2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (III-2), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also includes an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (III-2) has distinct N- and C-termini and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, AK289927, BC144446, CA429204, M94166
      UniProtKB/Swiss-Prot
      Q02297
      Conserved Domains (2) summary
      pfam02158
      Location:295484
      Neuregulin; Neuregulin family
      PHA02887
      Location:236279
      PHA02887; EGF-like protein; Provisional
    15. NM_001322207.1NP_001309136.1  pro-neuregulin-1, membrane-bound isoform isoform III-3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (III-3), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (III-3) has distinct N- and C-termini and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, AK289927, AK298132, BC144446, BQ018711, M94166
      UniProtKB/Swiss-Prot
      Q02297
      Conserved Domains (2) summary
      pfam02158
      Location:295483
      Neuregulin; Neuregulin family
      PHA02887
      Location:236279
      PHA02887; EGF-like protein; Provisional
    16. NM_004495.3NP_004486.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma

      See identical proteins and their annotated locations for NP_004486.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-gamma), which uses the type I promoter, lacks multiple 3' exons but contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (HRG-gamma) is shorter at the C-terminus, compared to isoform HRG-beta1.
      Source sequence(s)
      AC083977, AC103675, BC144446
      UniProtKB/TrEMBL
      Q7RTW5
      Conserved Domains (2) summary
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cl11960
      Location:53127
      Ig; Immunoglobulin domain
    17. NM_013956.4NP_039250.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1

      See identical proteins and their annotated locations for NP_039250.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-beta1), which uses the type I promoter, encodes isoform HRG-beta1 (also known as NDF-beta1a or HRG-beta1a).
      Source sequence(s)
      AC113209, AK097005, AK298132, BC006492, BC144446, CA429204, DA805080, M94166
      Consensus CDS
      CCDS6083.1
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      Q6PK61
      Related
      ENSP00000287842, OTTHUMP00000278916, ENST00000287842, OTTHUMT00000483442
      Conserved Domains (4) summary
      pfam02158
      Location:240635
      Neuregulin; Neuregulin family
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cd00054
      Location:190222
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    18. NM_013957.4NP_039251.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2

      See identical proteins and their annotated locations for NP_039251.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-beta2), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, compared to variant HRG-beta1, resulting in an isoform (HRG-beta2) that is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, AK097005, AK290730, AK298132, BC006492, CA429204, DA805080, M94165
      Consensus CDS
      CCDS6084.1
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      Q6PK61, Q7RTW3
      Related
      ENSP00000349275, OTTHUMP00000225420, ENST00000356819, OTTHUMT00000376467
      Conserved Domains (4) summary
      pfam02158
      Location:232627
      Neuregulin; Neuregulin family
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cd00054
      Location:190222
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    19. NM_013958.3NP_039252.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3

      See identical proteins and their annotated locations for NP_039252.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-beta3), which uses the type I promoter, lacks multiple 3' exons but contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (HRG-beta3, also known as GGF or GGFHFB1) is shorter at the C-terminus, compared to isoform HRG-beta1.
      Source sequence(s)
      AK097005, AK298132, M94165, M94168
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      A0A024QY88
      Conserved Domains (2) summary
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cl11960
      Location:53127
      Ig; Immunoglobulin domain
    20. NM_013959.3NP_039253.1  pro-neuregulin-1, membrane-bound isoform isoform SMDF

      See identical proteins and their annotated locations for NP_039253.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SMDF), which uses the type III promoter, is expressed mainly in the nervous system. It lacks multiple 5' and 3' exons but has alternate 5' and 3' terminal exons, and it thus differs in the 5' and 3' coding regions and in both UTRs, compared to variant HRG-beta1. The resulting isoform (SMDF, also known as NRG-III-beta3) has distinct N- and C-termini and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AK289927, M94168
      Consensus CDS
      CCDS6087.1
      UniProtKB/Swiss-Prot
      Q02297
      Related
      ENSP00000433289, OTTHUMP00000230605, ENST00000520502, OTTHUMT00000376979
      Conserved Domains (1) summary
      PHA02887
      Location:236279
      PHA02887; EGF-like protein; Provisional
    21. NM_013960.4NP_039254.1  pro-neuregulin-1, membrane-bound isoform isoform ndf43 proprotein

      See identical proteins and their annotated locations for NP_039254.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (ndf43), which uses the type I promoter, lacks two in-frame exons but contains a different in-frame exon in the central coding region, and it also contains an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43) has an alternate internal segment and a distinct C-terminus, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, AK097005, AK298132, BC006492, CA429204, DA805080, M94165, U02326
      Consensus CDS
      CCDS6086.1
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      Q6PK61
      Related
      ENSP00000428828, OTTHUMP00000225422, ENST00000521670, OTTHUMT00000376469
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:235424
      Neuregulin; Neuregulin family
    22. NM_013962.2NP_039256.2  pro-neuregulin-1, membrane-bound isoform isoform GGF2 precursor

      See identical proteins and their annotated locations for NP_039256.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GGF2), which uses the type II promoter, is expressed in the nervous system and functions as a neuronal signal that promotes the proliferation and survival of the oligodendrocyte and the myelinating cell. This variant contains alternate 5' and 3' terminal exons and thus differs in the 5' and 3' coding regions and in both UTRs, and it also lacks two alternate in-frame exons in the central coding region, compared to variant HRG-beta1. The resulting isoform (GGF2, also known as GGFHBS5) has distinct N- and C-termini, lacks an internal segment, and is shorter than isoform HRG-beta1.
      Source sequence(s)
      L12260, M94165, M94168
      Consensus CDS
      CCDS47836.1
      UniProtKB/Swiss-Prot
      Q02297
      Related
      ENSP00000434640, OTTHUMP00000230603, ENST00000520407, OTTHUMT00000376412
      Conserved Domains (3) summary
      cd05895
      Location:268342
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA02887
      Location:362405
      PHA02887; EGF-like protein; Provisional
      smart00410
      Location:258344
      IG_like; Immunoglobulin like
    23. NM_013964.4NP_039258.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-alpha proprotein

      See identical proteins and their annotated locations for NP_039258.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (HRG-alpha), which uses the type I promoter, lacks two in-frame exons but contains a different in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-alpha, also known as erbB2 or gp30/alpha 1) contains an alternate internal segment and is shorter than isoform HRG-beta1.
      Source sequence(s)
      AC113209, AK097005, AK298132, BC006492, CA429204, DA805080, M94165
      Consensus CDS
      CCDS6085.1
      UniProtKB/Swiss-Prot
      Q02297
      UniProtKB/TrEMBL
      Q6PK61
      Related
      ENSP00000384620, OTTHUMP00000274317, ENST00000405005, OTTHUMT00000472504
      Conserved Domains (4) summary
      pfam02158
      Location:235630
      Neuregulin; Neuregulin family
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cd00054
      Location:190222
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      31639222..32771716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544512.2XP_011542814.1  

      Related
      ENSP00000429067, OTTHUMP00000225398, ENST00000523534, OTTHUMT00000376413
      Conserved Domains (4) summary
      pfam02158
      Location:247642
      Neuregulin; Neuregulin family
      cd05895
      Location:60134
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:50136
      IG_like; Immunoglobulin like
      cd00054
      Location:197229
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. XM_017013365.1XP_016868854.1  

    3. XM_017013366.1XP_016868855.1  

    4. XM_017013371.1XP_016868860.1  

    5. XM_017013372.1XP_016868861.1  

    6. XM_017013367.1XP_016868856.1  

    7. XM_017013368.1XP_016868857.1  

    8. XM_005273486.3XP_005273543.1  

      Conserved Domains (2) summary
      pfam02158
      Location:290685
      Neuregulin; Neuregulin family
      cd00054
      Location:245277
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    9. XM_005273487.3XP_005273544.1  

      Conserved Domains (2) summary
      pfam02158
      Location:287682
      Neuregulin; Neuregulin family
      PHA03099
      Location:237326
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    10. XM_017013369.1XP_016868858.1  

    11. XM_017013370.1XP_016868859.1  

    12. XM_006716335.3XP_006716398.1  

      Conserved Domains (1) summary
      pfam02158
      Location:15410
      Neuregulin; Neuregulin family

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      31698194..32827151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)