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    Pth parathyroid hormone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24694, updated on 27-Mar-2016
    Official Symbol
    Pthprovided by RGD
    Official Full Name
    parathyroid hormoneprovided by RGD
    Primary source
    RGD:3440
    See related
    Ensembl:ENSRNOG00000014318
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pth1; Pthr1; PTH-(1-84)
    Summary
    regulates osteoblast proliferation and differentiation; involved in G-protein coupled receptor mediated adenylate cyclase activation [RGD, Feb 2006]
    Orthologs
    Location:
    1q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178215829..178218761, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (185183456..185186388, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene aryl hydrocarbon receptor nuclear translocator-like Neighboring gene BTB domain containing 10 Neighboring gene similar to Alpha-enolase (2-phospho-D-glycerate hydro-lyase) (Non-neural enolase) (NNE) (Enolase 1) Neighboring gene fatty acyl CoA reductase 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    parathyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptide hormone receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 1 parathyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bone resorption TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular macromolecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular macromolecule biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process in bone marrow IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process in bone marrow ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    ossification TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of bone mineralization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation in bone marrow IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation in bone marrow ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of osteoclast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoclast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to fibroblast growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to parathyroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    parathyroid hormone
    Names
    hypothalamic parathyroid hormone
    parathyrin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017044.1NP_058740.1  parathyroid hormone precursor

      See identical proteins and their annotated locations for NP_058740.1

      Status: PROVISIONAL

      Source sequence(s)
      X05721
      UniProtKB/Swiss-Prot
      P04089
      Related
      ENSRNOP00000019199, ENSRNOT00000019199
      Conserved Domains (1) summary
      pfam01279
      Location:29113
      Parathyroid; Parathyroid hormone family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      178215829..178218761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      165378267..165381199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)