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DKK1 dickkopf WNT signaling pathway inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 22943, updated on 17-May-2015
Official Symbol
DKK1provided by HGNC
Official Full Name
dickkopf WNT signaling pathway inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:2891
See related
Ensembl:ENSG00000107984; HPRD:05544; MIM:605189; Vega:OTTHUMG00000018247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SK; DKK-1
Summary
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
Orthologs
See DKK1 in MapViewer
Location:
10q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (52314281..52317657)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (54074041..54077417)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein kinase, cGMP-dependent, type I Neighboring gene uncharacterized LOC105378303 Neighboring gene PRKG1 antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 44 Neighboring gene protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
NHGRI GWA Catalog
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
NHGRI GWA Catalog
Genome-wide association study of chronic periodontitis in a general German population.
NHGRI GWA Catalog
Several common variants modulate heart rate, PR interval and QRS duration.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of dickkopf-1 in primary human osteoblasts PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor antagonist activity IDA
Inferred from Direct Assay
more info
PubMed 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis involved in differentiation IEA
Inferred from Electronic Annotation
more info
 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endoderm formation IEA
Inferred from Electronic Annotation
more info
 
extracellular negative regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cardiac muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mesodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of endodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
early endosome membrane TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dickkopf-related protein 1
Names
dickkopf-related protein 1
dickkopf 1 homolog
dickkopf related protein-1
dickkopf-1 like
dickkopf-like protein 1
hDkk-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012242.2NP_036374.1  dickkopf-related protein 1 precursor

    See identical proteins and their annotated locations for NP_036374.1

    Status: REVIEWED

    Source sequence(s)
    AC009986, AF127563, BU752259, BX952450
    Consensus CDS
    CCDS7246.1
    UniProtKB/TrEMBL
    I1W660
    UniProtKB/Swiss-Prot
    O94907
    Related
    ENSP00000363081, OTTHUMP00000019617, ENST00000373970, OTTHUMT00000048100
    Conserved Domains (1) summary
    pfam04706
    Location:84139
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    52314281..52317657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    54355855..54359231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)