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    Wt1 Wilms tumor 1 homolog [ Mus musculus (house mouse) ]

    Gene ID: 22431, updated on 25-Aug-2015
    Official Symbol
    Wt1provided by MGI
    Official Full Name
    Wilms tumor 1 homologprovided by MGI
    Primary source
    MGI:MGI:98968
    See related
    Ensembl:ENSMUSG00000016458; Vega:OTTMUSG00000014987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wt-1; D630046I19Rik
    Summary
    This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]
    Orthologs
    Location:
    2 55.06 cM; 2 E
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (105126529..105173614)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (104966686..105013771)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39899 Neighboring gene Wilms tumor 1 homolog, opposite strand Neighboring gene thioesterase superfamily member 7 Neighboring gene reticulocalbin 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    C2H2 zinc finger domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA splicing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Sertoli cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adrenal cortex formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adrenal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to gonadotropin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to gonadotropin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    coronary vasculature development TAS
    Traceable Author Statement
    more info
    PubMed 
    diaphragm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glomerular basement membrane development ISO
    Inferred from Sequence Orthology
    more info
     
    glomerular visceral epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glomerulus development ISO
    Inferred from Sequence Orthology
    more info
     
    gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal to epithelial transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesonephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephric S-shaped body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephric S-shaped body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mesenchymal cell apoptotic process involved in metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of metanephric glomerular mesangial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of metanephric ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    posterior mesonephric tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of organ formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sex determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sex determination ISO
    Inferred from Sequence Orthology
    more info
     
    single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thorax and anterior abdomen determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visceral serous pericardium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visceral serous pericardium development ISO
    Inferred from Sequence Orthology
    more info
     
    visceral serous pericardium development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    Wilms tumor protein homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144783.2NP_659032.3  Wilms tumor protein homolog

      Status: REVIEWED

      Source sequence(s)
      AL512584, BG087452, DQ537939
      Consensus CDS
      CCDS16496.2
      UniProtKB/TrEMBL
      Q199A7
      Related
      ENSMUSP00000117891, OTTMUSP00000015944, ENSMUST00000143043, OTTMUST00000035573
      Conserved Domains (5) summary
      COG5048
      Location:381509
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam02165
      Location:69389
      WT1; Wilm's tumor protein
      pfam13465
      Location:438462
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:398415
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:453473
      ZF_C2H2; Zn binding site [ion binding]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

      Range
      105126529..105173614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      106361212..106408919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)