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    SLT2 mitogen-activated serine/threonine-protein kinase SLT2 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 856425, updated on 27-Jun-2015
    Gene symbol
    SLT2
    Gene description
    mitogen-activated serine/threonine-protein kinase SLT2
    Primary source
    SGD:S000001072
    Locus tag
    YHR030C
    Gene type
    protein coding
    RNA name
    mitogen-activated serine/threonine-protein kinase SLT2
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BYC2; LYT2; MPK1; SLK2
    See SLT2 in MapViewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (168890..170344, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Dap2p Neighboring gene Yhi9p Neighboring gene Rrm3p Neighboring gene Erc1p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    barrier septum assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fungal-type cell wall biogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peroxisome degradation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription factor import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular bud neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular bud tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mating projection tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    mitogen-activated serine/threonine-protein kinase SLT2
    NP_011895.1
    • Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, cell cycle progression, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to phagophore assembly site (PAS); plays a role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; SLT2 has a paralog, KDX1, that arose from the whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      168890..170344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179160.1NP_011895.1  mitogen-activated serine/threonine-protein kinase SLT2 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_011895.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q00772
      Conserved Domains (2) summary
      cd07857
      Location:22355
      STKc_MPK1; Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1
      smart00220
      Location:23318
      S_TKc; Serine/Threonine protein kinases, catalytic domain