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    SEC63 protein-transporting protein SEC63 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854428, updated on 3-Jul-2016
    Gene symbol
    SEC63
    Gene description
    protein-transporting protein SEC63
    Primary source
    SGD:S000005780
    Locus tag
    YOR254C
    Gene type
    protein coding
    RNA name
    protein-transporting protein SEC63
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PTL1
    See SEC63 in Map Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (805032..807023, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tma16p Neighboring gene peptide alpha-N-acetyltransferase subunit NAT5 Neighboring gene Osw1p Neighboring gene putative zinc metalloprotease

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    protein transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    SRP-dependent cotranslational protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol to ER transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    posttranslational protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    posttranslational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Sec62/Sec63 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    protein-transporting protein SEC63
    NP_014897.1
    • Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec62p, Sec66p, and Sec72p

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      805032..807023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183673.1NP_014897.1  protein-transporting protein SEC63 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_014897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P14906
      Conserved Domains (3) summary
      cd06257
      Location:125185
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00611
      Location:240611
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG5407
      Location:1658
      SEC63; Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular transport]