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    Sell selectin, lymphocyte [ Mus musculus (house mouse) ]

    Gene ID: 20343, updated on 15-Nov-2015
    Official Symbol
    Sellprovided by MGI
    Official Full Name
    selectin, lymphocyteprovided by MGI
    Primary source
    MGI:MGI:98279
    See related
    Ensembl:ENSMUSG00000026581; Vega:OTTMUSG00000050837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lnhr; CD62L; Ly-22; Lyam1; Ly-m22; Lyam-1; LECAM-1; AI528707; L-selectin
    Orthologs
    See Sell in Epigenomics, MapViewer
    Location:
    1 H2.2; 1 71.37 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (164061813..164080785)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (165992207..166010916)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC055324 Neighboring gene methyltransferase like 18 Neighboring gene selectin, endothelial cell Neighboring gene selectin, platelet Neighboring gene predicted gene 16548 Neighboring gene coagulation factor V

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (15)  1 citation
    • Chemically induced (ENU) (1) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    glycolipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to ATP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    L-selectin
    Names
    CD62 antigen-like family member L
    LAM-1
    LECAM1
    leukocyte adhesion molecule 1
    leukocyte-endothelial cell adhesion molecule 1
    lymph node homing receptor
    lymphocyte antigen 22
    lymphocyte surface MEL-14 antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164059.1NP_001157531.1  L-selectin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC110499
      Consensus CDS
      CCDS48421.1
      UniProtKB/TrEMBL
      Q3TCF3
      Conserved Domains (2) summary
      cd00033
      Location:161219
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl02432
      Location:39157
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    2. NM_011346.2NP_035476.1  L-selectin isoform 1 precursor

      See identical proteins and their annotated locations for NP_035476.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA182222, AK137509, BY210690
      Consensus CDS
      CCDS35753.1
      UniProtKB/Swiss-Prot
      P18337
      UniProtKB/TrEMBL
      Q3UV83
      Related
      ENSMUSP00000027871, OTTMUSP00000069271, ENSMUST00000027871, OTTMUST00000128808
      Conserved Domains (3) summary
      cd00033
      Location:197255
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00054
      Location:160192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02432
      Location:39157
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

      Range
      164061813..164080785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496716.1XP_006496779.1  

      See identical proteins and their annotated locations for XP_006496779.1

      UniProtKB/TrEMBL
      B1B507
      Conserved Domains (3) summary
      cd00033
      Location:197255
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:39157
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      cd00054
      Location:160192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. XM_006496717.1XP_006496780.1  

      See identical proteins and their annotated locations for XP_006496780.1

      UniProtKB/TrEMBL
      B1B506
      Conserved Domains (3) summary
      cd00033
      Location:197255
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:39157
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      cd00054
      Location:160192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    3. XM_006496718.2XP_006496781.1  

      Conserved Domains (3) summary
      cd00033
      Location:197255
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00054
      Location:160192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02432
      Location:39157
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    Alternate Mm_Celera

    Genomic

    1. AC_000023.1 Alternate Mm_Celera

      Range
      166503711..166522465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)