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    Arrb1 arrestin, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 109689, updated on 8-Aug-2016
    Official Symbol
    Arrb1provided by MGI
    Official Full Name
    arrestin, beta 1provided by MGI
    Primary source
    MGI:MGI:99473
    See related
    Ensembl:ENSMUSG00000018909 Vega:OTTMUSG00000034019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW208571; 1200006I17Rik; G430100A01Rik
    Orthologs
    Location:
    7 E2; 7 54.09 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (99535486..99606772)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (106683996..106755281)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39056 Neighboring gene predicted gene, 40450 Neighboring gene predicted gene, 34172 Neighboring gene nuclear encoded tRNA glutamic acid 3 (anticodon CTC) Neighboring gene microRNA 326 Neighboring gene trophoblast glycoprotein-like Neighboring gene solute carrier organic anion transporter family, member 2b1 Neighboring gene predicted gene, 34280

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC124269, MGC124270

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    AP-2 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    V2 vasopressin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-1A adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-1B adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    follicle-stimulating hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphorylated amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    follicle-stimulating hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G-protein coupled receptor protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    beta-arrestin-1
    Names
    beta-arrestin1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177231.2NP_796205.1  beta-arrestin-1 isoform A

      See identical proteins and their annotated locations for NP_796205.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer protein (isoform A).
      Source sequence(s)
      AK147508, AK147566
      Consensus CDS
      CCDS40032.1
      UniProtKB/Swiss-Prot
      Q8BWG8
      Related
      ENSMUSP00000095866, OTTMUSP00000046443, ENSMUST00000098266, OTTMUST00000085875
      Conserved Domains (2) summary
      smart01017
      Location:193356
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:18174
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. NM_178220.3NP_835738.1  beta-arrestin-1 isoform B

      See identical proteins and their annotated locations for NP_835738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) lacks an alternate exon in the 3' coding region compared to variant a. The resulting protein (isoform B) is shorter but has the same N- and C-termini compared to isoform A.
      Source sequence(s)
      AK090090, AK147508, AK147566
      Consensus CDS
      CCDS21484.1
      UniProtKB/Swiss-Prot
      Q8BWG8
      Related
      ENSMUSP00000032995, OTTMUSP00000046444, ENSMUST00000032995, OTTMUST00000085876
      Conserved Domains (2) summary
      smart01017
      Location:193348
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:18174
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      99535486..99606772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507198.3XP_006507261.1  

      Conserved Domains (2) summary
      smart01017
      Location:230393
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:55211
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. XM_006507199.3XP_006507262.1  

      Conserved Domains (2) summary
      smart01017
      Location:230385
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:55211
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    3. XM_006507200.2XP_006507263.1  

      Conserved Domains (2) summary
      smart01017
      Location:188351
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:13169
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    4. XM_011241644.2XP_011239946.1  

      Conserved Domains (2) summary
      smart01017
      Location:205368
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:30186
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RNA

    1. XR_378207.3 RNA Sequence

    2. XR_378208.3 RNA Sequence