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PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [ Homo sapiens (human) ]

Gene ID: 5209, updated on 6-Jul-2014
Official Symbol
PFKFB3provided by HGNC
Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3provided by HGNC
Primary source
HGNC:8874
Locus tag
RP11-298K24.3
See related
Ensembl:ENSG00000170525; HPRD:05612; MIM:605319; Vega:OTTHUMG00000017621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFK2; IPFK2
See PFKFB3 in Epigenomics, MapViewer
Location:
10p15.1
Exon count :
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (6144880..6235545)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (6186843..6277508)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 17 Neighboring gene uncharacterized LOC101928080 Neighboring gene microRNA 3155a Neighboring gene microRNA 3155b Neighboring gene syndecan binding protein (syntenin) pseudogene 1 Neighboring gene uncharacterized LOC399715 Neighboring gene developmental pluripotency associated 5 pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMPK signaling, organism-specific biosystem (from WikiPathways)
    AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Fructose and mannose metabolism, organism-specific biosystem (from KEGG)
    Fructose and mannose metabolism, organism-specific biosystem
    Fructose and mannose metabolism
  • Fructose and mannose metabolism, conserved biosystem (from KEGG)
    Fructose and mannose metabolism, conserved biosystem
    Fructose and mannose metabolism
  • Glucose metabolism, organism-specific biosystem (from REACTOME)
    Glucose metabolism, organism-specific biosystemGlucose is the major form in which dietary sugars are made available to cells of the human body. Its breakdown is a major source of energy for all cells, and is essential for the brain and red blood ...
  • Glycogen storage diseases, organism-specific biosystem (from REACTOME)
    Glycogen storage diseases, organism-specific biosystemThe regulated turnover of glycogen plays a central, tissue-specific role in the maintenance of blood glucose levels and in the provision of glucose to tissues such as muscle and brain in response to ...
  • Glycolysis, organism-specific biosystem (from REACTOME)
    Glycolysis, organism-specific biosystemThe reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructo...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    HIF-1-alpha transcription factor network, organism-specific biosystem
    HIF-1-alpha transcription factor network
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Myoclonic epilepsy of Lafora, organism-specific biosystem (from REACTOME)
    Myoclonic epilepsy of Lafora, organism-specific biosystemLafora disease is a progressive neurodegenerative disorder with onset typically late in childhood, characterized by seizures and progressive neurological deterioration and death within ten years of o...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
6-phosphofructo-2-kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fructose-2,6-bisphosphate 2-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process TAS
Traceable Author Statement
more info
 
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
carbohydrate phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
fructose 2,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
fructose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process TAS
Traceable Author Statement
more info
 
glycolytic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
iPFK-2
PFK/FBPase 3
6PF-2-K/Fru-2,6-P2ase 3
renal carcinoma antigen NY-REN-56
6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme
6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase
fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase
inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
NP_001138915.1
NP_001269559.1
NP_004557.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145443.1NP_001138915.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2

    See proteins identical to NP_001138915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL359960, D49817, DC323583
    Consensus CDS
    CCDS44353.1
    UniProtKB/Swiss-Prot
    Q16875
    Related
    ENSP00000369115, OTTHUMP00000019039, ENST00000379789, OTTHUMT00000046646
    Conserved Domains (2) summary
    cd07067
    Location:228414
    Blast Score: 310
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:4226
    Blast Score: 1045
    6PF2K; 6-phosphofructo-2-kinase
  2. NM_001282630.1NP_001269559.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 3

    See proteins identical to NP_001269559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI633567, AK304450, AL359960, DC316967, L77662
    Consensus CDS
    CCDS60479.1
    UniProtKB/Swiss-Prot
    Q16875
    Conserved Domains (2) summary
    cd07067
    Location:262448
    Blast Score: 310
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:41260
    Blast Score: 1055
    6PF2K; 6-phosphofructo-2-kinase
  3. NM_004566.3NP_004557.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1

    See proteins identical to NP_004557.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. It encodes isoform 1.
    Source sequence(s)
    AI633567, AL359960, BC040482, DA315586, DB068734
    Consensus CDS
    CCDS7078.1
    UniProtKB/Swiss-Prot
    Q16875
    Related
    ENSP00000369100, OTTHUMP00000019040, ENST00000379775, OTTHUMT00000046647
    Conserved Domains (2) summary
    cd07067
    Location:248434
    Blast Score: 310
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    Blast Score: 1052
    6PF2K; 6-phosphofructo-2-kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    6144880..6235545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252463.1XP_005252520.1  

    See proteins identical to XP_005252520.1

    UniProtKB/Swiss-Prot
    Q16875
    Conserved Domains (2) summary
    cd07067
    Location:248434
    Blast Score: 310
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    Blast Score: 1058
    6PF2K; 6-phosphofructo-2-kinase
  2. XM_005252464.1XP_005252521.1  

    Conserved Domains (2) summary
    cd07067
    Location:248434
    Blast Score: 309
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    Blast Score: 1043
    6PF2K; 6-phosphofructo-2-kinase

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    6113180..6203192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    6186886..6276773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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