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    Tal1 T cell acute lymphocytic leukemia 1 [ Mus musculus (house mouse) ]

    Gene ID: 21349, updated on 26-Jun-2016
    Official Symbol
    Tal1provided by MGI
    Official Full Name
    T cell acute lymphocytic leukemia 1provided by MGI
    Primary source
    MGI:MGI:98480
    See related
    Ensembl:ENSMUSG00000028717 Vega:OTTMUSG00000008586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hpt; Scl; tal-1; bHLHa17; SCL/tal-1
    Orthologs
    Location:
    4 D1; 4 52.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (115056426..115071755)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (114732132..114744360)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene cytidine monophosphate (UMP-CMP) kinase 1 Neighboring gene Scl/Tal1 interrupting locus Neighboring gene predicted gene, 33786 Neighboring gene PDZK1 interacting protein 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1, opposite strand

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    astrocyte fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemangioblast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chromatin assembly or disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    spinal cord association neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with Lsd1/2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    T-cell acute lymphocytic leukemia protein 1 homolog
    Names
    T-cell acute lymphocytic leukemia 1
    stem cell protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287388.1NP_001274317.1  T-cell acute lymphocytic leukemia protein 1 homolog

      See identical proteins and their annotated locations for NP_001274317.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK157852, BC063060
      Consensus CDS
      CCDS18486.1
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7
      Related
      ENSMUSP00000125202, OTTMUSP00000048409, ENSMUST00000161601, OTTMUST00000088749
      Conserved Domains (1) summary
      cd00083
      Location:185243
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    2. NM_011527.3NP_035657.1  T-cell acute lymphocytic leukemia protein 1 homolog

      See identical proteins and their annotated locations for NP_035657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      BC063060
      Consensus CDS
      CCDS18486.1
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7
      Related
      ENSMUSP00000030489, OTTMUSP00000008932, ENSMUST00000030489, OTTMUST00000019470
      Conserved Domains (1) summary
      cd00083
      Location:185243
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      115056426..115071755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502912.3XP_006502975.1  

      See identical proteins and their annotated locations for XP_006502975.1

      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7
      Related
      ENSMUSP00000124983, OTTMUSP00000048410, ENSMUST00000162489, OTTMUST00000088750
      Conserved Domains (1) summary
      cd00083
      Location:185243
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    2. XM_006502916.2XP_006502979.1  

      See identical proteins and their annotated locations for XP_006502979.1

      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7
      Conserved Domains (1) summary
      cd00083
      Location:185243
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    3. XM_006502910.3XP_006502973.1  

      See identical proteins and their annotated locations for XP_006502973.1

      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7
      Conserved Domains (1) summary
      cd00083
      Location:185243
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    4. XM_006502914.3XP_006502977.1  

      See identical proteins and their annotated locations for XP_006502977.1

      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7
      Conserved Domains (1) summary
      cd00083
      Location:185243
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    5. XM_006502913.3XP_006502976.1  

      See identical proteins and their annotated locations for XP_006502976.1

      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7
      Conserved Domains (1) summary
      cd00083
      Location:185243
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    6. XM_006502915.3XP_006502978.1  

      See identical proteins and their annotated locations for XP_006502978.1

      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7
      Conserved Domains (1) summary
      cd00083
      Location:185243
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    7. XM_006502909.2XP_006502972.1  

      Conserved Domains (1) summary
      cd00083
      Location:191249
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...