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    CXCR4 chemokine (C-X-C motif) receptor 4 [ Homo sapiens (human) ]

    Gene ID: 7852, updated on 30-Jun-2015
    Official Symbol
    CXCR4provided by HGNC
    Official Full Name
    chemokine (C-X-C motif) receptor 4provided by HGNC
    Primary source
    HGNC:HGNC:2561
    See related
    Ensembl:ENSG00000121966; HPRD:01217; MIM:162643; Vega:OTTHUMG00000153583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E
    Summary
    This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Orthologs
    See CXCR4 in Epigenomics, MapViewer
    Location:
    2q21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (136114349..136118155, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (136871919..136875725, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mannosidase, endo-alpha-like pseudogene Neighboring gene aspartyl-tRNA synthetase Neighboring gene DARS antisense RNA 1 Neighboring gene uncharacterized LOC105373632 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene 2 Neighboring gene ubiquitin B pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Warts, hypogammaglobulinemia, infections, and myelokathexis
    MedGen: C0472817 OMIM: 193670 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.
    NHGRI GWA Catalog
    Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of chemokine (C-X-C motif) receptor 4 (CXCR4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
    Knockdown of chemokine (C-X-C motif) receptor 4 (CXCR4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CXCR4, a 45kDa cellular membrane protein, interacts with the cell surface HIV-1 gp120-CD4 complex and acts as a coreceptor to preferentially support T cell line-tropic HIV-1 Env-mediated cell fusion and HIV-1 infection PubMed
    env CCR5 expression inhibits HIV-1 gp120 binding to CD4/CXCR4 complexes in 293T cells PubMed
    env CCR5 expression inhibits HIV-1 gp120-mediated early actin rearrangement and -induced LIMK1 activation and cofilin phosphorylation in CD4/CXCR4 expressing 293T cells PubMed
    env HIV-1 gp120-enhanced CD4/CXCR4 conformation changes are regulated by CCR5 expression in 293T cells PubMed
    env SMS2, but not SMS1, is involved in enhancement of HIV-1 gp120/gp41-mediated membrane fusion through CD4 receptor and CCR5/CXCR4 coreceptors PubMed
    env Positively charged Lys/Arg at position 322 in the V3 of gp120 and negatively charged Asp/Glu at position 440 in in the C4 of gp120 occur more frequently in CXCR4-using viruses PubMed
    env Analysis of the distribution of V3 loop's net charge and flexibility in HIV-1 gp120 shows its selection more positive toward CXCR4 than CCR5 PubMed
    env V1, V2, and V3 domains and N-linked glycosylation sites of HIV-1 gp120 confer coreceptor tropism; loss of an N-linked glycosylation site within V3 has a major influence on the virus switching from CCR5 to CXCR4 tropism in a V3 charge-dependent manner PubMed
    env HIV-1 gp120-CXCR4 signaling triggers cofilin activation and actin dynamics, which are important for a post entry process leading to viral nuclear localization PubMed
    env The specific amino acids 298-329 in the V3 loop of HIV-1 gp120 that determine cellular tropism also regulate chemokine coreceptor (CCR5 or CXCR4) preference for cell entry by the virus PubMed
    env The interaction of CXCR4 with HIV-1 gp120 mediates gp120-induced CXCR3 and EMAP2 expression in human lung microvascular endothelial cells PubMed
    env HIV-1 gp120 upregulates the expression of chemokine (C-X-C motif) receptor 4 (CXCR4) in human B cells PubMed
    env HIV-1 gp120 induces mucus formation through CXCR4 on normal human bronchial epithelial cells PubMed
    env Antibodies to specific epitopes of the CCR5 or CXCR4 chemokine receptors inhibit the entry of M-tropic, T-tropic, or dual-tropic HIV-1 into target cells by blocking the interaction of the receptors with the HIV-1 gp120/CD4 complex PubMed
    env Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes PubMed
    env HIV-1 gp120-induced dephosphorylation of KV2.1 and re-localization of KV2.1 on the soma and proximal dendrites results in disruption of the clustered KV2.1 via activation of CCR5/CXCR4 co-receptors or SDF-1 alpha treatment PubMed
    env Stimulating CXCR4 with HIV-1 envelope glycoprotein 120 induces macropinocytosis, which may have implications for the internalization of HIV-1 PubMed
    env The coreceptor-binding site in HIV-1 gp120 is centered around an anti-parallel beta-sheet structure 'bridging sheet domain'; mutations in and adjacent to this domain have greater impact on CXCR4-mediated fusion than on CCR5-mediated fusion PubMed
    env Amino acid variants at positions 261 and 263 within the gp41-interactive region of gp120 and a variant at position 326 within the gp120 V3 loop are associated with efficient CXCR4-mediated monocyte-derived macrophages (MDM) entry PubMed
    env The interaction of HIV-1 gp120 with CXCR4 is inhibited by neutralizing monoclonal antibodies that prevent the interaction of gp120 with CD4 and by antibodies specific for the gp120 V2 and V3 loops PubMed
    env The entry of T cell-tropic HIV-1 isolates is blocked by SDF-1 or CXCR4 antagonists, which bind to CXCR4 PubMed
    env HIV-1 gp120-induced synapse loss requires sequential activation of CXCR4, IL-1beta receptor, and NMDA receptor PubMed
    env HIV-1 gp120-mediated CXCR4 activation induces upregulation of neuronal nicotinic receptor, alpha-7 PubMed
    env HIV-1 gp120 binding to CXCR4 results in cellular proliferation in osteoblast-like cells PubMed
    env HIV-1 X4-tropic gp120 upregulates alpha-SMA (ACTA2) and collagen I alpha 1 expression via the ERK1/2 pathway in a CXCR4-dependent manner in activated human hepatic stellate cells PubMed
    env Deaminases APOBEC3F- and APOBEC3G-mediated G-to-A mutations in the V3 region of HIV-1 gp120 lead to the co-receptor switch from R5 to X4 strains PubMed
    env Adsorption of multivalent gp120-containing HIV-1 virion particles into CD4+ T lymphocytes results in segregation of CD4 and CXCR4 into distinct lipid micro domains PubMed
    env Binding of HIV-1 gp120 to CXCR4 induces cell apoptosis through decreased binding of 14-3-3tau to the pro-apoptotic molecule, Bad PubMed
    env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
    env HIV-1 gp120 and gp41-mediated virus-cell fusion is more dependent on viral core maturation for viruses bearing CXCR4-tropic gp120 than for those bearing CCR5-tropic gp120 PubMed
    env HIV-1 gp120 promotes filamin binding to both CD4 and CXCR4 PubMed
    env HIV-1 gp120-induced Ca(2+) fluxing is CD4 dependent and coreceptor specific, and is mediated by the CCR5 and CXCR4 coreceptors PubMed
    env HIV-1 and gp120 can induce breast cancer cell apoptosis through gp120-CXCR4 interaction without a CD4-induced conformational change of gp120 PubMed
    env CCL2 upregulates CXCR4 on resting CD4(+) T cells in a CCR2-dependent mechanism, increases the ability of these cells to be chemoattracted to CXCR4 using gp120 and renders them more permissive to X4-tropic HIV-1 infection PubMed
    env Association and clustering of CD4-CXCR4 induced by HIV-1 gp120 requires moesin-mediated anchoring of actin in the plasma membrane PubMed
    env The presence of HIV-1 envelope glycoprotein (gp120) in the rat preoptic anterior hypothalamus provokes fever via interaction CXCR4 pathway PubMed
    env IgE-FcepsilonRI coaggregation mediated by HIV-1 gp120 accelerates maximal CXCR4 expression and susceptibility to X4 virus by progenitor mast cells (prMCs) PubMed
    env HIV-1 gp120 from a T-cell-tropic virus causes CD4-dependent antagonism of CXCR4 response to SDF-1alpha, whereas gp120 from macrophage-tropic viruses causes CD4-dependent antagonism of CCR5 response to MIP-1alpha PubMed
    env HIV-1 gp120-induced neuronal cell death involves p38 mitogen-activated protein kinase; both HIV-1 coreceptors, CCR5 and CXCR4, can mediate HIV-1 gp120-induced neurotoxicity PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
    env N-glycosylation at N11 of CXCR4 inhibits the binding of CXCR4 to CXCR4- and CCR5-tropic HIV-1 gp120 PubMed
    env HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase PubMed
    env Stimulation of neurons with HIV-1 gp120 or the endogenous CXCR4 agonist, SDF-1 alpha, results in inducing p53 activity and expression of the p53 pro-apoptotic target Apaf-1 PubMed
    env In T cell lines and peripheral blood mononuclear cells, HIV-1 gp120-induced apoptosis is regulated by CD45 through the induction of CD45 association with the HIV-1 coreceptor CXCR4 PubMed
    env Raji-DC-SIGN cells preferentially enhance CXCR4 usage of dual-tropic HIV-1 with higher V3 charges in gp120 PubMed
    env Transcription factor E2F1 is necessary for neuronal cell death induced by HIV-1 gp120 via neuronal CXCR4 PubMed
    env An HIV-1 gp120 mutant with a deletion of amino acids E61 to S85 in its C1 region exhibits a strong interaction with CXCR4, although CD4 binding is undetectable PubMed
    env HIV-1 gp120 inhibits monocyte response to chemokines and activation by chemoattractants by interacting with CD4 and downregulating the cell surface receptor CXCR4 PubMed
    env Conversion of Asp-187 to the neutral amino acid Val in the second extracellular loop of CXCR4, which is a coreceptor for dual-tropic and T-tropic strains of HIV-1, unmasked activity with M-tropic gp120 in fusion and infection experiments PubMed
    env The death rate of CD8+ T cells by apoptosis, which is induced by HIV-1 gp120 from CXCR4-tropic HIV strains or by the ligand of the chemokine receptor CXCR4 (SDF-1), is increased markedly during HIV infection of peripheral blood mononuclear cells PubMed
    env A gp120 protein derived from the HIV-1 IIIB strain utilizes CXCR4 as a primary receptor in the absence of CD4 on T- and B- lymphoid cell lines PubMed
    env A synthetic peptide corresponding to amino acid residues 414-434 of HIV-1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R PubMed
    env HIV-1 gp120, but not SDF-1alpha, induces rapid tyrosine phosphorylation of src-like kinase p56lck in CD4+ T cells, whereas both gp120 and SDF-1alpha cause phosphorylation of CXCR4 PubMed
    env Cathepsin D may induce conformational modification of HIV-1 gp120, allowing direct interaction with the CXCR4 coreceptor and enhancing HIV-1 infectivity and entry into cells PubMed
    env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed
    env T-tropic HIV-1 gp120s are capable of priming phorbol ester (PMA) induced co-down-modulation of gp120 complexes with tailless CD4 by interacting with CXCR4, whereas M-tropic gp120 are not, even in the presence of CCR5 PubMed
    env The cis expression of DC-SIGN on multiple lymphoid cell lines enables more efficient entry and replication of CXCR4-tropic and CCR5/CXCR4 dual-tropic HIV-1 through its binding to the HIV-1 gp120-CD4-CXCR4 complex PubMed
    env SDF-1alpha and HIV-1 gp120 induce the appearance of pseudopodia in which CD26 and CXCR4 colocalize PubMed
    env Production of the C-X-C chemokine growth-regulated oncogene alpha (GRO-alpha) is markedly stimulated by CXCR4-tropic HIV-1; HIV-1 gp120 engagement of CXCR4 initiates the stimulation of GRO-alpha production, which is blocked by antibodies to CXCR4 PubMed
    env Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation PubMed
    env A CD4-independent, CXCR4-tropic HIV-1 isolate directly interacts with CXCR4 through its mutated gp120, and downregulates CXCR4 membrane expression in CD4-positive or -negative cells chronically infected with the strain PubMed
    env The proteasome inhibitors, lactacystin and epoxomicin, inhibit SDF-1alpha and gp120 protein-induced down-modulation of CXCR4 in Jurkat cells PubMed
    env Kappa-opioid receptor (KOR) agonist treatment of CD4(+) lymphocytes inhibits HIV-1 envelope gp120/41-mediated membrane fusion via downregulation of CXCR4 PubMed
    env HIV-1 gp120 interactions with CXCR4 and CCR5 lead to the cross-desensitization of CCR6 and CCR7; this gp120-induced inhibition is strictly dependent on CXCR4 or CCR5 and lipid rafts but not on CD4 or V(H)3-expressing BCR PubMed
    env Brain-derived neurotrophic factor (BDNF) prevents HIV-1 gp120-mediated neuronal cell death by reducing the levels of CXC chemokine receptor-4 (CXCR4), a receptor that mediates HIV-1 gp120-induced apoptosis PubMed
    env Binding of HIV-1 gp120 to SupT1 lymphoblastoid cells triggers association between CXCR4 and ganglioside GM3 PubMed
    env Engagement of the CCR5 and CXCR4 receptors by HIV-1 gp120 induces tyrosine phosphorylation of the protein tyrosine kinase Pyk2 PubMed
    env The first (residues 1-39) and third (residues 176-202) extracellular domains of human CXCR4 are required for the functional interaction with HIV-1 gp120; HIV-1 strains have different requirements for their interaction with CXCR4 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 envelope protein gp140 oligomers enter cells by binding to the chemokine receptor CXCR4 PubMed
    env HIV-1 Env co-localizes with CXCR4 and downregulates the coreceptor in HIV-1 infected human cells PubMed
    Envelope transmembrane glycoprotein gp41 env SMS2, but not SMS1, is involved in enhancement of HIV-1 gp120/gp41-mediated membrane fusion through CD4 receptor and CCR5/CXCR4 coreceptors PubMed
    env HIV-1 gp120 and gp41 form a transitional complex with the CD4 receptor and CCR5/CXCR4 coreceptors during virus-cell and cell-cell membrane fusion PubMed
    env The engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process results in a quick HIV-1 gp41 six-helix bundle formation PubMed
    env Sequences in the gp41 transmembrane (TM) can modulate coreceptor specificity and that Env sequences other than that of V3 may facilitate efficient CXCR4-mediated entry PubMed
    env The interactions between HIV-1 gp120/41, CD4 receptor, and CXCR4 result in cell-virus and cell-cell membrane fusion PubMed
    env Peptide P5 (residues 628-683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, inhibits HIV-1 envelope mediated cell-cell fusion and infection of PBMCs by both X4- and R5-tropic HIV-1 strains PubMed
    Nef nef HIV-1 Nef downregulates the second major HIV-1 coreceptor, CXCR4, from the surface of HIV-infected primary CD4 T lymphocytes with efficiencies comparable to the natural CXCR4 ligand, stromal cell-derived factor-1 alpha PubMed
    nef HIV-1 Nef co-localizes with CXCR4, AIP4, NEDD4, CD63/LAMP-1-positive vesicles, and HRS/VPS27-positive ESCRT-0 structures PubMed
    nef The Lys residues (K327/331/333) in the C-terminal tail of CXCR4 and the catalytic Cys830 in the HECT domain of AIP4 are critically required for HIV-1 Nef-mediated downregulation of CXCR4 PubMed
    nef HIV-1 Nef dramatically enhances the binding of AIP4 with CXCR4 and alanine substitutions at positions Q297 and N329 of AIP4 eliminate this binding PubMed
    nef HIV-1 Nef-mediated CXCR4 downregulation is dependent on ubiquitinylation, which is mediated by the E3 ubiquitin ligase AIP4 PubMed
    nef Specific sequences spanning amino-acids 50 to 60 and 170 to 180 in the HIV-1 Nef protein appear to be necessary for Nef-induced apoptosis as well as for physical interaction with CXCR4 receptors PubMed
    nef The inhibition of T-cell migration of HIV-1 Nef expressing cells by CD3 stimulation results from the inhibition of surface expression of CXCR4 PubMed
    nef HIV-1 Nef significantly upregulates the expression of CXCR4 on the Caco-2 cell surface PubMed
    nef The HIV-1 Nef highly conserved valine-glycine-phenylalanine amino acid triplet (VGF) motif, which links the acidic cluster and the proline-rich motif, is important for downregulation of CXCR4 and MHC-I PubMed
    nef Disruption of the proline-rich region of HIV-1 Nef inhibits T-cell migration to SDF-1 alpha, suggesting Nef occupies a position in the CXCR4-mediated signaling pathway that is upstream of an SH3-dependent pathway PubMed
    nef HIV-1 Nef expression from unintegrated HIV-1 DNA downregulates the surface levels of CD4, CCR5, and CXCR4 on T-lymphocytes and monocytes PubMed
    nef An intracellular signaling pathway mediated by the binding of SDF-1alpha and CXCR4 is inhibited by Nef in both Jurkat T cells and primary peripheral CD4+ T lymphocytes PubMed
    nef HIV-1 Nef-induced increase in monocyte migration may be caused through CXCR4 function PubMed
    nef The interaction of HIV-1 Nef with the cell surface receptor CXCR4 induces apoptosis in CD4+ T cells, an effect that can be inhibited with CXCR4 antibodies, as well as the endogenous CXCR4 ligand SDF-1alpha PubMed
    Pr55(Gag) gag HIV-1 Gag co-localizes with CXCR4 in HIV-1 infected CD4 + T cells PubMed
    gag Expression of HIV-1 Gag attenuates SDF-1-mediated downregulation of CXCR4. The effect of Gag is dependent on a TSG101 interacting motif within the C-terminal p6 region of Gag PubMed
    Rev rev Rev(34-50) peptide with AAAAC at the C-terminus inhibits HIV-1 replication by antagonism of Rev and the CXCR4 co-receptor PubMed
    Tat tat HIV-1 Tat upregulates CXCR4 expression on lymphocytes, monocytes/macrophages and erythroid cells, indicating a role for Tat in HIV-1 pathogenesis and in promoting the infectivity of HIV-1 PubMed
    tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
    tat HIV-1 Tat increases CXCL12-induced internalization of CXCR4, and the Tat-mediated CXCR4 internalization requires activity of protein kinase C (zeta) PubMed
    tat HIV-1 Tat binds to CXCR4, competes with the natural ligand of CXCR4, SDF-1alpha, and selectively inhibits the entry and replication of X4-tropic HIV-1 in peripheral blood mononuclear cells (PBMCs), indicating a role for Tat in selecting against X4 virus PubMed
    tat HIV-1 Tat can inhibit CXCR4-mediated functions by interfering with the chemotactic activity of SDF-1/CXCL12, an effect mediated by Tat amino acids 25-31 PubMed
    Vpu vpu HIV-1 Vpu downregulates the cell surface expression of chemokine (C-X-C motif) receptor 4 (CXCR4, CD184) PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-X-C chemokine receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    G-protein coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    coreceptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin light chain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPK activity TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    dendritic cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    entry into host cell TAS
    Traceable Author Statement
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    myelin maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    viral process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasmic membrane-bounded vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    C-X-C chemokine receptor type 4
    Names
    CD184 antigen
    LPS-associated protein 3
    SDF-1 receptor
    fusin
    leukocyte-derived seven transmembrane domain receptor
    lipopolysaccharide-associated protein 3
    neuropeptide Y receptor Y3
    neuropeptide Y3 receptor
    seven transmembrane helix receptor
    seven-transmembrane-segment receptor, spleen
    stromal cell-derived factor 1 receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011587.1 RefSeqGene

      Range
      5001..8807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_51

    mRNA and Protein(s)

    1. NM_001008540.1NP_001008540.1  C-X-C chemokine receptor type 4 isoform a

      See identical proteins and their annotated locations for NP_001008540.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as CXCR4-Lo, represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF147204
      Consensus CDS
      CCDS33295.1
      UniProtKB/Swiss-Prot
      P61073
      Related
      ENSP00000386884, OTTHUMP00000204155, ENST00000409817, OTTHUMT00000331734
      Conserved Domains (2) summary
      pfam12109
      Location:1042
      CXCR4_N; CXCR4 Chemokine receptor N terminal
      pfam00001
      Location:65306
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_003467.2NP_003458.1  C-X-C chemokine receptor type 4 isoform b

      See identical proteins and their annotated locations for NP_003458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter N-terminus when compared to isoform a.
      Source sequence(s)
      AC068492, AF147204, D10924
      Consensus CDS
      CCDS46420.1
      UniProtKB/Swiss-Prot
      P61073
      Related
      ENSP00000241393, OTTHUMP00000204154, ENST00000241393, OTTHUMT00000331732
      Conserved Domains (2) summary
      pfam12109
      Location:638
      CXCR4_N; CXCR4 Chemokine receptor N terminal
      pfam00001
      Location:61302
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      136114349..136118155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      136877321..136881126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)