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RGS4 regulator of G-protein signaling 4 [ Homo sapiens (human) ]

Gene ID: 5999, updated on 19-Jul-2014
Official Symbol
RGS4provided by HGNC
Official Full Name
regulator of G-protein signaling 4provided by HGNC
Primary source
HGNC:10000
Locus tag
RP11-430G6.1
See related
Ensembl:ENSG00000117152; HPRD:03947; MIM:602516; Vega:OTTHUMG00000034417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP4; SCZD9
Summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
See RGS4 in Epigenomics, MapViewer
Location:
1q23.3
Exon count :
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (163068606..163076802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163038396..163046592)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene chromosome 1 open reading frame 110 Neighboring gene uncharacterized LOC101928404 Neighboring gene regulator of G-protein signaling 5 Neighboring gene tRNA nucleotidyl transferase, CCA-adding, 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of regulator of G-protein signaling 4 (RGS4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (z) signalling events, organism-specific biosystemThe heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
protein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
regulator of G-protein signaling 4
Names
regulator of G-protein signaling 4
schizophrenia disorder 9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023312.1 

    Range
    5001..13197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001102445.2NP_001095915.1  regulator of G-protein signaling 4 isoform 1

    See proteins identical to NP_001095915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL583850, DC334933, DQ346664
    Consensus CDS
    CCDS44270.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000397181, OTTHUMP00000228806, ENST00000421743, OTTHUMT00000382515
    Conserved Domains (1) summary
    cd08714
    Location:160273
    Blast Score: 559
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
  2. NM_001113380.1NP_001106851.1  regulator of G-protein signaling 4 isoform 3

    See proteins identical to NP_001106851.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL583850, EF054877
    Consensus CDS
    CCDS44272.1
    UniProtKB/Swiss-Prot
    P49798
    Conserved Domains (1) summary
    cd08714
    Location:45158
    Blast Score: 533
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
  3. NM_001113381.1NP_001106852.1  regulator of G-protein signaling 4 isoform 4

    See proteins identical to NP_001106852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an internal coding exon in the 3' region, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK093959, AL583850, DA660695
    Consensus CDS
    CCDS44271.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000356884, OTTHUMP00000032324, ENST00000367908, OTTHUMT00000083199
  4. NM_005613.5NP_005604.1  regulator of G-protein signaling 4 isoform 2

    See proteins identical to NP_005604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL583850, DC318279, DQ346663
    Consensus CDS
    CCDS1243.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000356885, OTTHUMP00000032322, ENST00000367909, OTTHUMT00000083197
    Conserved Domains (1) summary
    cd08714
    Location:63176
    Blast Score: 543
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    163068606..163076802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    134283724..134291924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    164461279..164469481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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