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RAD51C DNA repair protein RAD51 homolog 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819136, updated on 8-Jan-2015
Gene symbol
RAD51C
Gene description
DNA repair protein RAD51 homolog 3
Primary source
TAIR:AT2G45280
Locus tag
AT2G45280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRAD51C; F4L23.21; RAD51C; RAS associated with diabetes protein 51C
Summary
Encodes a protein similar to RAD51C involved in double stranded break repair via homologous recombination. Sensitive to DSB induced by Mitomycin C and gamma irradiation, interacts with Atxrcc3 in yeast two-hybrid assay. Required for female meiosis but not critical for mitosis under normal conditions.
See RAD51C in MapViewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (18670009..18672277)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene glycoprotease 1 Neighboring gene transketolase Neighboring gene 3-phosphoshikimate 1-carboxyvinyltransferase / 5-enolpyruvylshikimate-3-phosphate / EPSP synthase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

  • Homologs of the RAD51C gene: The RAD51C gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, rice, and frog.
NM_001202820.1
NM_130091.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent ATPase activity IEA
Inferred from Electronic Annotation
more info
 
damaged DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
recombinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
DNA methylation RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-dependent DNA replication RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
RNA processing RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
chromatin modification RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via homologous recombination RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
double-strand break repair via synthesis-dependent strand annealing IDA
Inferred from Direct Assay
more info
PubMed 
embryo sac egg cell differentiation RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
female meiotic division IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene silencing by RNA RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
male meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
male meiosis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
pollen development RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
positive regulation of transcription, DNA-templated RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
post-translational protein modification RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
protein targeting to mitochondrion RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
reciprocal meiotic recombination RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
regulation of DNA replication RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
regulation of cell cycle RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
regulation of transcription, DNA-templated RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
response to ionizing radiation RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
somatic cell DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic cell DNA recombination RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
synapsis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
cell RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
DNA repair protein RAD51 homolog 3
NP_001189749.1
  • RAS associated with diabetes protein 51C (RAD51C); CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: DNA repair (Rad51) family protein (TAIR:AT3G22880.1).
NP_566040.1
  • RAS associated with diabetes protein 51C (RAD51C); CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: DNA repair (Rad51) family protein (TAIR:AT3G22880.1); Has 5546 Blast hits to 5533 proteins in 2007 species: Archae - 678; Bacteria - 2546; Metazoa - 757; Fungi - 474; Plants - 412; Viruses - 0; Other Eukaryotes - 679 (source: NCBI BLink).

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 

    Range
    18670009..18672277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130091.1NP_566040.1  DNA repair protein RAD51 homolog 3 [Arabidopsis thaliana]

    See proteins identical to NP_566040.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GXF0
    Conserved Domains (1) summary
    cd01123
    Location:105351
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
  2. NM_001202820.1NP_001189749.1  DNA repair protein RAD51 homolog 3 [Arabidopsis thaliana]

    See proteins identical to NP_001189749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4IW45
    Conserved Domains (1) summary
    cd01123
    Location:129375
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...