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    Pecam1 platelet/endothelial cell adhesion molecule 1 [ Mus musculus (house mouse) ]

    Gene ID: 18613, updated on 19-Jul-2016
    Official Symbol
    Pecam1provided by MGI
    Official Full Name
    platelet/endothelial cell adhesion molecule 1provided by MGI
    Primary source
    MGI:MGI:97537
    See related
    Ensembl:ENSMUSG00000020717 Vega:OTTMUSG00000003418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd31; Pecam; C85791; PECAM-1
    Orthologs
    Location:
    11; 11 E1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (106654213..106750623, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106515532..106576595, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene predicted gene, 36220 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene testis expressed gene 2 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

    Markers

    Homology

    Clone Names

    • MGC102160

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    diapedesis ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of Stat5 protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    smooth muscle contractile fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    platelet endothelial cell adhesion molecule

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032378.2NP_001027550.1  platelet endothelial cell adhesion molecule isoform 2 precursor

      See identical proteins and their annotated locations for NP_001027550.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 3' coding exon but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AK169431, BC085502, BE692027, BY781761
      Consensus CDS
      CCDS25558.1
      UniProtKB/Swiss-Prot
      Q08481
      Related
      ENSMUSP00000099358, OTTMUSP00000003452, ENSMUST00000103069, OTTMUST00000007191
      Conserved Domains (4) summary
      smart00408
      Location:328377
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:316393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain
    2. NM_001305157.1NP_001292086.1  platelet endothelial cell adhesion molecule isoform 3 precursor

      See identical proteins and their annotated locations for NP_001292086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' coding exon, which results in a frameshift, compared to variant 1. It encodes isoform 3 which has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK084527, AK169431, BE692027, BY781761
      Consensus CDS
      CCDS79069.1
      UniProtKB/Swiss-Prot
      Q08481
      Related
      ENSMUSP00000102408, OTTMUSP00000003455, ENSMUST00000106796, OTTMUST00000007194
      Conserved Domains (4) summary
      smart00408
      Location:328377
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:316393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain
    3. NM_001305158.1NP_001292087.1  platelet endothelial cell adhesion molecule isoform 4 precursor

      See identical proteins and their annotated locations for NP_001292087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame 5' coding exon, and contains an alternate 3' coding exon which results in a frameshift, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK037551, AK084527, AK169431, BE692027, BY781761
      Consensus CDS
      CCDS79068.1
      UniProtKB/Swiss-Prot
      Q08481
      UniProtKB/TrEMBL
      Q8CAW4
      Related
      ENSMUSP00000138959, OTTMUSP00000065669, ENSMUST00000183610, OTTMUST00000117407
      Conserved Domains (4) summary
      smart00408
      Location:227276
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:215292
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain
    4. NM_008816.3NP_032842.2  platelet endothelial cell adhesion molecule isoform 1 precursor

      See identical proteins and their annotated locations for NP_032842.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK084527, BE692027, BY781761
      Consensus CDS
      CCDS25559.1
      UniProtKB/Swiss-Prot
      Q08481
      Related
      ENSMUSP00000079664, OTTMUSP00000003454, ENSMUST00000080853, OTTMUST00000007193
      Conserved Domains (4) summary
      smart00408
      Location:328377
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:316393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      106654213..106750623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248792.1XP_011247094.1  

      See identical proteins and their annotated locations for XP_011247094.1

      UniProtKB/Swiss-Prot
      Q08481
      Related
      ENSMUSP00000067111, OTTMUSP00000003453, ENSMUST00000068021, OTTMUST00000007192
      Conserved Domains (4) summary
      smart00408
      Location:328377
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:316393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain
    2. XM_006532474.1XP_006532537.1  

      Conserved Domains (4) summary
      smart00408
      Location:328377
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:316393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain
    3. XM_006532473.1XP_006532536.1  

      Conserved Domains (4) summary
      smart00408
      Location:328377
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:316393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain
    4. XM_011248793.1XP_011247095.1  

      Conserved Domains (4) summary
      smart00408
      Location:328377
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:316393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain
    5. XM_006532472.1XP_006532535.1  

      Conserved Domains (4) summary
      smart00408
      Location:328377
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33117
      IG_like; Immunoglobulin like
      pfam13895
      Location:316393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33107
      Ig; Immunoglobulin domain