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    Jun jun proto-oncogene [ Mus musculus (house mouse) ]

    Gene ID: 16476, updated on 27-Jun-2015
    Official Symbol
    Junprovided by MGI
    Official Full Name
    jun proto-oncogeneprovided by MGI
    Primary source
    MGI:MGI:96646
    See related
    Ensembl:ENSMUSG00000052684; Vega:OTTMUSG00000008035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP-1; Junc; c-jun
    Orthologs
    Location:
    4 43.34 cM; 4 C5-C7
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (95049036..95052222, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (94715727..94718913, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene myb-like, SWIRM and MPN domains 1 Neighboring gene predicted gene 12694 Neighboring gene jun proto-oncogene, opposite strand Neighboring gene predicted gene 12708 Neighboring gene predicted gene, 32240

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    HMG box domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding RNA polymerase II transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SMAD protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to potassium ion starvation ISO
    Inferred from Sequence Orthology
    more info
     
    leading edge cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning ISO
    Inferred from Sequence Orthology
    more info
     
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA-templated transcription, initiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to muscle stretch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to radiation ISO
    Inferred from Sequence Orthology
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcriptional repressor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Preferred Names
    transcription factor AP-1
    Names
    transcription factor AP-1
    AH119
    AP1
    Jun oncogene
    V-jun avian sarcoma virus 17 oncogene homolog
    activator protein 1
    immediate early
    jun A
    proto-oncogene c-jun

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010591.2NP_034721.1  transcription factor AP-1

      See identical proteins and their annotated locations for NP_034721.1

      Status: VALIDATED

      Source sequence(s)
      AK159196, BY106462
      Consensus CDS
      CCDS18364.1
      UniProtKB/Swiss-Prot
      P05627
      UniProtKB/TrEMBL
      Q52L79
      Related
      ENSMUSP00000102711, OTTMUSP00000008346, ENSMUST00000107094, OTTMUST00000018173
      Conserved Domains (2) summary
      pfam03957
      Location:5244
      Jun; Jun-like transcription factor
      cd14696
      Location:257317
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

      Range
      95049036..95052222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000026.1 Alternate Mm_Celera

      Range
      93436543..93439728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)