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    Kcnd2 potassium channel, voltage-gated Shal-related subfamily D, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65180, updated on 27-Jun-2015
    Official Symbol
    Kcnd2provided by RGD
    Official Full Name
    potassium channel, voltage-gated Shal-related subfamily D, member 2provided by RGD
    Primary source
    RGD:68393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RK5; Kv4.2; Shal1
    Summary
    a potassium channel responsible for transient outward K+ currents in cardiomyocytes [RGD, Feb 2006]
    Orthologs
    See Kcnd2 in MapViewer
    Location:
    4q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (48309283..48817720)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (48099455..48609215)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC498971 Neighboring gene hypothetical LOC100364378 Neighboring gene uncharacterized LOC102556178 Neighboring gene uncharacterized LOC103692079 Neighboring gene uncharacterized LOC103692080 Neighboring gene 60S ribosomal protein L3 pseudogene Neighboring gene protein SDA1 homolog Neighboring gene tubulin beta chain-like Neighboring gene tetraspanin 12 Neighboring gene cytochrome c oxidase, subunit VIc-like Neighboring gene inhibitor of growth family, member 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    A-type (transient outward) potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    A-type (transient outward) potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    A-type (transient outward) potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    action potential ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    locomotor rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    potassium voltage-gated channel subfamily D member 2
    Names
    potassium voltage-gated channel subfamily D member 2
    potassium voltage gated channel, Shal-related family, member 2
    potassium voltage-gated channel, Shal-related subfamily, member 2
    voltage-gated potassium channel subunit Kv4.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031730.2NP_113918.2  potassium voltage-gated channel subfamily D member 2 precursor

      See identical proteins and their annotated locations for NP_113918.2

      Status: VALIDATED

      Source sequence(s)
      AABR07060003, AC117109, CB790894, CO393575, M59980
      UniProtKB/TrEMBL
      G3V986
      UniProtKB/Swiss-Prot
      Q63881
      Conserved Domains (5) summary
      pfam11601
      Location:328
      Shal-type; Shal-type voltage-gated potassium channels
      pfam00520
      Location:231405
      Ion_trans; Ion transport protein
      pfam02214
      Location:43132
      BTB_2; BTB/POZ domain
      pfam07885
      Location:331406
      Ion_trans_2; Ion channel
      pfam11879
      Location:445547
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      48309283..48817720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762830.1XP_008761052.1  

      Conserved Domains (1) summary
      pfam11879
      Location:70172
      DUF3399; Domain of unknown function (DUF3399)

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      44984114..45483230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)