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Foxa2 forkhead box A2 [ Mus musculus (house mouse) ]

Gene ID: 15376, updated on 5-May-2015
Official Symbol
Foxa2provided by MGI
Official Full Name
forkhead box A2provided by MGI
Primary source
MGI:MGI:1347476
See related
Ensembl:ENSMUSG00000037025; Vega:OTTMUSG00000015678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnf3b; Tcf3b; Hnf-3b; Tcf-3b; HNF3beta; HNF3-beta
Orthologs
See Foxa2 in MapViewer
Location:
2 G3; 2 73.38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (148042877..148046969, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (147868614..147872705, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35579 Neighboring gene RIKEN cDNA 9030622O22 gene Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene predicted gene, 36597

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
anatomical structure formation involved in morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
anatomical structure morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation in hindbrain IGI
Inferred from Genetic Interaction
more info
PubMed 
cell differentiation in hindbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
connective tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral neural tube patterning IDA
Inferred from Direct Assay
more info
PubMed 
dorsal/ventral neural tube patterning IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
ectoderm formation IGI
Inferred from Genetic Interaction
more info
PubMed 
endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
epithelial tube branching involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
lung epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of detection of glucose IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter by glucose IDA
Inferred from Direct Assay
more info
PubMed 
neuron fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter by glucose IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase III promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
primitive streak formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of steroid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-6 TAS
Traceable Author Statement
more info
PubMed 
signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
somite rostral/caudal axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hepatocyte nuclear factor 3-beta
Names
hepatocyte nuclear factor 3-beta
HNF-3-beta
forkhead box protein A2
hepatocyte nuclear factor 3 beta (winged helix transcription factor)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291065.1NP_001277994.1  hepatocyte nuclear factor 3-beta isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL845297, L10409
    Consensus CDS
    CCDS71157.1
    UniProtKB/TrEMBL
    G5E8P5
    UniProtKB/Swiss-Prot
    P35583
    Related
    ENSMUSP00000105590, OTTMUSP00000016694, ENSMUST00000109964, OTTMUST00000037260
    Conserved Domains (3) summary
    cd00059
    Location:165242
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...
    pfam08430
    Location:23164
    Fork_head_N; Forkhead N-terminal region
    pfam09354
    Location:380454
    HNF_C; HNF3 C-terminal domain
  2. NM_001291067.1NP_001277996.1  hepatocyte nuclear factor 3-beta isoform c

    See identical proteins and their annotated locations for NP_001277996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL845297, BU055166
    Conserved Domains (3) summary
    cd00059
    Location:129206
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...
    pfam08430
    Location:1128
    Fork_head_N; Forkhead N-terminal region
    pfam09354
    Location:344418
    HNF_C; HNF3 C-terminal domain
  3. NM_010446.3NP_034576.2  hepatocyte nuclear factor 3-beta isoform b

    See identical proteins and their annotated locations for NP_034576.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL845297, L10409
    Consensus CDS
    CCDS16836.1
    UniProtKB/Swiss-Prot
    P35583
    Related
    ENSMUSP00000045918, OTTMUSP00000016693, ENSMUST00000047315, OTTMUST00000037259
    Conserved Domains (3) summary
    cd00059
    Location:159236
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...
    pfam08430
    Location:17158
    Fork_head_N; Forkhead N-terminal region
    pfam09354
    Location:374448
    HNF_C; HNF3 C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    148042877..148046969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    149306402..149310523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)