Display Settings:

Format

Send to:

Choose Destination

GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [ Homo sapiens (human) ]

Gene ID: 10399, updated on 11-Sep-2014
Official Symbol
GNB2L1provided by HGNC
Official Full Name
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1provided by HGNC
Primary source
HGNC:HGNC:4399
Locus tag
HLC7
See related
Ensembl:ENSG00000204628; HPRD:01503; MIM:176981; Vega:OTTHUMG00000163380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H12.3; HLC-7; PIG21; RACK1; Gnb2-rs1
See GNB2L1 in Epigenomics, MapViewer
Location:
5q35.3
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (181236928..181243906, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180663928..180671209, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microRNA 4638 Neighboring gene tripartite motif containing 41 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene uncharacterized LOC101928649 Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene tripartite motif containing 52 Neighboring gene TRIM52 antisense RNA 1 (head to head)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef The binding of HIV-1 Nef with Rack1 (receptor for activated C kinase 1) is mediated by amino acids 34-143 in Nef; Rack1 acts as a Nef intracellular docking site, bringing Nef and PKCs together PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, guanine nucleotide binding protein, beta polypeptide 2-like 1 (GNB2L1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
matrix gag Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
 
ion channel inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex scaffold TAS
Traceable Author Statement
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
 
protein kinase C binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
receptor tyrosine kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
gastrulation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hydrogen peroxide-induced neuron death IGI
Inferred from Genetic Interaction
more info
 
negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cAMP catabolic process IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 
positive regulation of cyclic-nucleotide phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein homooligomerization IDA
Inferred from Direct Assay
more info
 
positive regulation of protein homooligomerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic cup IDA
Inferred from Direct Assay
more info
 
small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
guanine nucleotide-binding protein subunit beta-2-like 1
Names
guanine nucleotide-binding protein subunit beta-2-like 1
lung cancer oncogene 7
proliferation-inducing gene 21
receptor for activated C kinase 1
human lung cancer oncogene 7 protein
receptor of activated protein kinase C 1
cell proliferation-inducing gene 21 protein
guanine nucleotide binding protein beta polypeptide 2-like 1
guanine nucleotide-binding protein subunit beta-like protein 12.3
protein homologous to chicken B complex protein, guanine nucleotide binding

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006098.4NP_006089.1  guanine nucleotide-binding protein subunit beta-2-like 1

    See proteins identical to NP_006089.1

    Status: VALIDATED

    Source sequence(s)
    AK222488, BC029996, M24194
    Consensus CDS
    CCDS34324.1
    UniProtKB/TrEMBL
    E9KL35
    UniProtKB/Swiss-Prot
    P63244
    Related
    ENSP00000366013, OTTHUMP00000223930, ENST00000376817, OTTHUMT00000373429
    Conserved Domains (2) summary
    COG2319
    Location:2310
    Blast Score: 375
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:7311
    Blast Score: 725
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    181236928..181243906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    175390873..175397848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    180096332..180103310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)