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    Ppara peroxisome proliferator activated receptor alpha [ Mus musculus (house mouse) ]

    Gene ID: 19013, updated on 24-Apr-2016
    Official Symbol
    Pparaprovided by MGI
    Official Full Name
    peroxisome proliferator activated receptor alphaprovided by MGI
    Primary source
    MGI:MGI:104740
    See related
    Ensembl:ENSMUSG00000022383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppar; Nr1c1; AW742785; PPARalpha; PPAR-alpha; 4933429D07Rik
    Orthologs
    Location:
    15 E2; 15 40.42 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (85728192..85806851)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (85565994..85637281)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene long noncoding RNA near Ppara Neighboring gene microRNA let7b Neighboring gene predicted gene, 34622 Neighboring gene cysteine rich, DPF motif domain containing 1 Neighboring gene polycystin (PKD) family receptor for egg jelly

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
      Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
    • Glucagon signaling pathway, conserved biosystem (from KEGG)
      Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
      Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
    • Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
      Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
    • PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem (from LIPID MAPS)
      PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem
      PPAR (Peroxisome proliferator-activated receptor) signaling pathway
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, organism-specific biosystem (from WikiPathways)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    NFAT protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enamel mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    glucose metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of appetite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    peroxisome proliferator-activated receptor alpha
    Names
    nuclear receptor subfamily 1 group C member 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113418.1NP_001106889.1  peroxisome proliferator-activated receptor alpha

      See identical proteins and their annotated locations for NP_001106889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC117784, AI118064, AK081709
      Consensus CDS
      CCDS27721.1
      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Related
      ENSMUSP00000105050, OTTMUSP00000027778, ENSMUST00000109423, OTTMUST00000057582
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    2. NM_011144.6NP_035274.2  peroxisome proliferator-activated receptor alpha

      See identical proteins and their annotated locations for NP_035274.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC117784, AI118064, AK035676
      Consensus CDS
      CCDS27721.1
      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Related
      ENSMUSP00000105049, OTTMUSP00000027777, ENSMUST00000109422, OTTMUST00000057581
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

      Range
      85728192..85806851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245518.1XP_011243820.1  

      See identical proteins and their annotated locations for XP_011243820.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    2. XM_011245517.1XP_011243819.1  

      See identical proteins and their annotated locations for XP_011243819.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    3. XM_011245516.1XP_011243818.1  

      See identical proteins and their annotated locations for XP_011243818.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    4. XM_006520624.2XP_006520687.1  

      Conserved Domains (2) summary
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      cl11397
      Location:201386
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    5. XM_006520619.1XP_006520682.1  

      See identical proteins and their annotated locations for XP_006520682.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Related
      ENSMUSP00000059719, OTTMUSP00000027779, ENSMUST00000057979, OTTMUST00000057583
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    6. XM_011245519.1XP_011243821.1  

      See identical proteins and their annotated locations for XP_011243821.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    7. XM_006520623.2XP_006520686.1  

      See identical proteins and their annotated locations for XP_006520686.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    8. XM_006520621.2XP_006520684.1  

      See identical proteins and their annotated locations for XP_006520684.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    9. XM_006520620.2XP_006520683.1  

      See identical proteins and their annotated locations for XP_006520683.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    10. XM_006520622.2XP_006520685.1  

      See identical proteins and their annotated locations for XP_006520685.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    Alternate Mm_Celera

    Genomic

    1. AC_000037.1 Alternate Mm_Celera

      Range
      87868281..87938913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)