Display Settings:

Format

Send to:

Choose Destination

WFDC2 WAP four-disulfide core domain 2 [ Homo sapiens (human) ]

Gene ID: 10406, updated on 22-Feb-2015
Official Symbol
WFDC2provided by HGNC
Official Full Name
WAP four-disulfide core domain 2provided by HGNC
Primary source
HGNC:HGNC:15939
See related
Ensembl:ENSG00000101443; HPRD:11684; Vega:OTTHUMG00000032594
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HE4; WAP5; EDDM4; dJ461P17.6
Summary
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Orthologs
See WFDC2 in MapViewer
Location:
20q13.12
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (45469754..45481532)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44098229..44110172)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class T Neighboring gene microRNA 6812 Neighboring gene uncharacterized LOC101927326 Neighboring gene ribosomal protein L5 pseudogene 2 Neighboring gene serine peptidase inhibitor, Kunitz type, 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Voxelwise genome-wide association study (vGWAS).
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC57529

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aspartic-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space TAS
Traceable Author Statement
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
WAP four-disulfide core domain protein 2
Names
WAP four-disulfide core domain protein 2
WAP domain containing protein HE4-V4
epididymal protein 4
epididymal secretory protein E4
epididymis-specific, whey-acidic protein type, four-disulfide core
major epididymis-specific protein E4
putative protease inhibitor WAP5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006103.3NP_006094.3  WAP four-disulfide core domain protein 2 precursor

    See proteins identical to NP_006094.3

    Status: REVIEWED

    Source sequence(s)
    BI759775, X63187
    Consensus CDS
    CCDS35501.1
    UniProtKB/Swiss-Prot
    Q14508
    Related
    ENSP00000361761, OTTHUMP00000031141, ENST00000372676, OTTHUMT00000079476
    Conserved Domains (2) summary
    cd00199
    Location:61123
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
    pfam00095
    Location:3273
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38 Primary Assembly

    Range
    45469754..45481532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    44000939..44012717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 Alternate HuRef

    Range
    40839873..40851651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_080733.1: Suppressed sequence

    Description
    NM_080733.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_080734.1: Suppressed sequence

    Description
    NM_080734.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_080735.1: Suppressed sequence

    Description
    NM_080735.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_080736.1: Suppressed sequence

    Description
    NM_080736.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.