Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    BDNF brain-derived neurotrophic factor [ Homo sapiens (human) ]

    Gene ID: 627, updated on 26-Jul-2015
    Official Symbol
    BDNFprovided by HGNC
    Official Full Name
    brain-derived neurotrophic factorprovided by HGNC
    Primary source
    HGNC:HGNC:1033
    See related
    Ensembl:ENSG00000176697; HPRD:00214; MIM:113505; Vega:OTTHUMG00000178797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANON2; BULN2
    Summary
    The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
    Orthologs
    See BDNF in Epigenomics, MapViewer
    Location:
    11p13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (27654893..27722058, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27676440..27743605, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BDNF antisense RNA Neighboring gene ribosomal protein S25 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 678 Neighboring gene chromobox homolog 3 pseudogene 1 Neighboring gene heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Bulimia nervosa 1
    MedGen: C1843776 OMIM: 607499 GeneReviews: Not available
    Compare labs
    Bulimia nervosa 2
    MedGen: C1853220 OMIM: 610269 GeneReviews: Not available
    Compare labs
    Congenital central hypoventilation Compare labs
    Obsessive-compulsive disorder
    MedGen: C1834037 OMIM: 164230 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    NHGRI GWA Catalog
    Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
    NHGRI GWA Catalog
    Genome wide association study identifies KCNMA1 contributing to human obesity.
    NHGRI GWA Catalog
    Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
    NHGRI GWA Catalog
    Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Co-exposure of human fetal neurons to brain-derived neurotrophic factor (BDNF) and HIV-1 gp120 leads to a dose-dependent increase in BDNF-induced somatostatin (SRIF) production PubMed
    Tat tat Human BDNF is protective to neuroblastoma cells exposed to HIV-1 Tat PubMed
    tat HIV-1 Tat increases proapoptotic proBDNF and decreases the mature BDNF protein in hippocampal neurons PubMed

    Go to the HIV-1, Human Interaction Database

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
      BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • FSH signaling pathway, organism-specific biosystem (from WikiPathways)
      FSH signaling pathway, organism-specific biosystemThe Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH)...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      p75(NTR)-mediated signaling, organism-specific biosystem
      p75(NTR)-mediated signaling
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC34632

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin TRKB receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    axon target recognition IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to norepinephrine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    chronic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    collateral sprouting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    inhibitory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    inner ear development IEA
    Inferred from Electronic Annotation
    more info
     
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    mechanoreceptor differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of striated muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    nerve development IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuron recognition IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glucocorticoid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of retinal cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of short-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    response to L-glutamate IEA
    Inferred from Electronic Annotation
    more info
     
    response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to anesthetic IEA
    Inferred from Electronic Annotation
    more info
     
    response to auditory stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to fluoxetine IEA
    Inferred from Electronic Annotation
    more info
     
    response to food IEA
    Inferred from Electronic Annotation
    more info
     
    response to hormone IEA
    Inferred from Electronic Annotation
    more info
     
    response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to light intensity IEA
    Inferred from Electronic Annotation
    more info
     
    response to potassium ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    taste bud development IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic membrane-bounded vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial crista IEA
    Inferred from Electronic Annotation
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    brain-derived neurotrophic factor
    Names
    abrineurin
    neurotrophin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011794.1 RefSeqGene

      Range
      5001..72164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001143805.1NP_001137277.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137277.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as IIa or BDNF2A, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF674517
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000432035, OTTHUMP00000232006, ENST00000525950, OTTHUMT00000388086
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    2. NM_001143806.1NP_001137278.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137278.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), also known as IIb or BDNF2B, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF674518
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000379302, OTTHUMP00000232022, ENST00000395978, OTTHUMT00000388105
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    3. NM_001143807.1NP_001137279.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137279.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), also known as III or BDNF3, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF674520
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000435805, OTTHUMP00000232021, ENST00000532997, OTTHUMT00000388104
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    4. NM_001143808.1NP_001137280.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137280.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), also known as Va, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF689011
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000379307, OTTHUMP00000232018, ENST00000395983, OTTHUMT00000388101
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    5. NM_001143809.1NP_001137281.1  brain-derived neurotrophic factor isoform d preproprotein

      See identical proteins and their annotated locations for NP_001137281.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), also known as Vb, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) contains a longer N-terminus compared to isoform a.
      Source sequence(s)
      EF689012
      UniProtKB/Swiss-Prot
      P23560
      Conserved Domains (1) summary
      pfam00243
      Location:159276
      NGF; Nerve growth factor family
    6. NM_001143810.1NP_001137282.1  brain-derived neurotrophic factor isoform e

      See identical proteins and their annotated locations for NP_001137282.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), also known as V-VIII, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (e) contains a longer N-terminus compared to isoform a.
      Source sequence(s)
      EF689019
      Consensus CDS
      CCDS44558.1
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000414303, OTTHUMP00000232019, ENST00000438929, OTTHUMT00000388102
      Conserved Domains (1) summary
      pfam00243
      Location:212329
      NGF; Nerve growth factor family
    7. NM_001143811.1NP_001137283.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137283.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), also known as V-VIII-VIIIh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF689020
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000389564, ENST00000420794
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    8. NM_001143812.1NP_001137284.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137284.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), also known as Vh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      CX751420, EF689013
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000435564, OTTHUMP00000232016, ENST00000530861, OTTHUMT00000388099
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    9. NM_001143813.1NP_001137285.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137285.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), also known as VIa, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF689014
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000432376, OTTHUMP00000232015, ENST00000533246, OTTHUMT00000388098
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    10. NM_001143814.1NP_001137286.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137286.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), also known as VIb-IXbd, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF689016
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000400502, OTTHUMP00000232014, ENST00000418212, OTTHUMT00000388097
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    11. NM_001143816.1NP_001137288.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137288.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), also known as IXabd, differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF689010
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000389345, OTTHUMP00000232039, ENST00000439476, OTTHUMT00000388134
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    12. NM_001709.4NP_001700.2  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001700.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as VIb or BDNF5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF689015
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000349084, OTTHUMP00000232013, ENST00000356660, OTTHUMT00000388096
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    13. NM_170731.4NP_733927.1  brain-derived neurotrophic factor isoform b preproprotein

      See identical proteins and their annotated locations for NP_733927.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as I, BDNF1, or 1-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) contains a longer N-terminus compared to isoform a.
      Source sequence(s)
      EF689021
      Consensus CDS
      CCDS7865.1
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000320002, OTTHUMP00000232043, ENST00000314915, OTTHUMT00000388138
      Conserved Domains (1) summary
      pfam00243
      Location:138255
      NGF; Nerve growth factor family
    14. NM_170732.4NP_733928.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_733928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as IIc, BDNF2C, or 2-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF674519
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000379305, OTTHUMP00000232005, ENST00000395981, OTTHUMT00000388085
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    15. NM_170733.3NP_733929.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_733929.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as IV, BDNF4, or 3-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF674521
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000379304, ENST00000395980
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family
    16. NM_170734.3NP_733930.1  brain-derived neurotrophic factor isoform c preproprotein

      See identical proteins and their annotated locations for NP_733930.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as VIIb, BDNF6B, or 4I-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) contains a longer N-terminus compared to isoform a.
      Source sequence(s)
      EF689018
      Consensus CDS
      CCDS41628.1
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000379309, OTTHUMP00000232041, ENST00000395986, OTTHUMT00000388136
      Conserved Domains (1) summary
      pfam00243
      Location:145262
      NGF; Nerve growth factor family
    17. NM_170735.5NP_733931.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_733931.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as IX, represents the longest transcript. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF689009
      Consensus CDS
      CCDS7866.1
      UniProtKB/TrEMBL
      A0A0E3SU01
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000437138, OTTHUMP00000232040, ENST00000525528, OTTHUMT00000388135
      Conserved Domains (1) summary
      pfam00243
      Location:130247
      NGF; Nerve growth factor family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      27654893..27722058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520280.1XP_011518582.1  

      See identical proteins and their annotated locations for XP_011518582.1

      UniProtKB/Swiss-Prot
      P23560
      Conserved Domains (1) summary
      pfam00243
      Location:212329
      NGF; Nerve growth factor family

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      27675184..27742527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001143815.1: Suppressed sequence

      Description
      NM_001143815.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript, which contains non-consensus splice sites in the 5' UTR.