Display Settings:

Format

Send to:

Choose Destination

nhr-49 Protein NHR-49 [ Caenorhabditis elegans ]

Gene ID: 172839, updated on 7-Sep-2014
Gene symbol
nhr-49
Gene description
Protein NHR-49
Locus tag
CELE_K10C3.6
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (old-lineage: Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
See nhr-49 in MapViewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.7 (9869709..9874115)

Chromosome I - NC_003279.7Genomic Context describing neighboring genes Neighboring gene Protein K10C3.4 Neighboring gene Protein K10C3.5 Neighboring gene Protein INX-20 Neighboring gene Protein NHR-69

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
nematode larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
Protein NHR-49
NP_001251234.1
  • C. elegans NHR-49 protein; contains similarity to Pfam domain PF00104 Ligand-binding domain of nuclear hormone receptor contains similarity to Interpro domains IPR001723 (Steroid hormone receptor), IPR000536 (Nuclear hormone receptor, ligand-binding, core);~Confirmed by transcript evidence
NP_492612.1
  • Confirmed by transcript evidence;~Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains)
NP_492613.1
  • C. elegans NHR-49 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR001723 (Steroid hormone receptor), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core);~Confirmed by transcript evidence
NP_871798.1
  • Confirmed by transcript evidence;~Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains)
NP_871799.1
  • Confirmed by transcript evidence;~Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.7 

    Range
    9869709..9874115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181998.4NP_871798.1  Protein NHR-49, isoform c [Caenorhabditis elegans]

    See proteins identical to NP_871798.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45666
    Conserved Domains (2) summary
    cd06960
    Location:35110
    Blast Score: 413
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:228382
    Blast Score: 323
    HOLI; Ligand binding domain of hormone receptors
  2. NM_181999.4NP_871799.1  Protein NHR-49, isoform d [Caenorhabditis elegans]

    See proteins identical to NP_871799.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45666
    Conserved Domains (2) summary
    cd06960
    Location:2095
    Blast Score: 411
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:213367
    Blast Score: 323
    HOLI; Ligand binding domain of hormone receptors
  3. NM_060211.4NP_492612.1  Protein NHR-49, isoform a [Caenorhabditis elegans]

    See proteins identical to NP_492612.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45666
    Conserved Domains (2) summary
    cd06960
    Location:1186
    Blast Score: 410
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:204358
    Blast Score: 326
    HOLI; Ligand binding domain of hormone receptors
  4. NM_060212.4NP_492613.1  Protein NHR-49, isoform b [Caenorhabditis elegans]

    See proteins identical to NP_492613.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45666
    Conserved Domains (2) summary
    cd06960
    Location:1186
    Blast Score: 410
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    cl11397
    Location:195392
    Blast Score: 332
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  5. NM_001264305.1NP_001251234.1  Protein NHR-49, isoform e [Caenorhabditis elegans]

    See proteins identical to NP_001251234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E5QCI8
    Conserved Domains (1) summary
    cl11397
    Location:73270
    Blast Score: 324
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators