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    Tnf tumor necrosis factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24835, updated on 3-Jul-2016
    Official Symbol
    Tnfprovided by RGD
    Official Full Name
    tumor necrosis factorprovided by RGD
    Primary source
    RGD:3876
    See related
    Ensembl:ENSRNOG00000055156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnfa; RATTNF; TNF-alpha
    Summary
    acts as a cytokine; binds TNF receptors; plays a role in regulation of cell proliferation, induction of apoptosis, and inflammatory response [RGD, Feb 2006]
    Location:
    20p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5189382..5192000, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (6936229..6938847)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene natural cytotoxicity triggering receptor 3 Neighboring gene leukocyte specific transcript 1 Neighboring gene lymphotoxin beta Neighboring gene lymphotoxin-alpha-like Neighboring gene antigen peptide transporter 2

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    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystem
      mTOR signaling pathway

    Markers

    Homology

    Clone Names

    • MGC124630

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    tumor necrosis factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acute inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    chronic inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    defense response ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digestive tract development ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell proliferation involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    humoral immune response ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development ISO
    Inferred from Sequence Orthology
    more info
     
    necroptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    necroptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of L-glutamate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of alkaline phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of branching involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytokine secretion involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of growth of symbiont in host ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NFAT protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood microparticle formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcidiol 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chronic inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fever generation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of humoral immune response mediated by circulating immunoglobulin ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-18 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte adhesion to arterial endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of superoxide dismutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translational initiation by iron ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vitamin D biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of branching involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of immunoglobulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    response to gold nanoparticle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal muscle contraction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    tumor necrosis factor
    Names
    cachectin
    tumor necrosis factor (TNF superfamily, member 2)
    tumor necrosis factor alpha
    tumor necrosis factor ligand superfamily member 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012675.3NP_036807.1  tumor necrosis factor

      See identical proteins and their annotated locations for NP_036807.1

      Status: VALIDATED

      Source sequence(s)
      BX883046
      UniProtKB/Swiss-Prot
      P16599
      Related
      ENSRNOP00000074520, ENSRNOT00000079677
      Conserved Domains (1) summary
      cd00184
      Location:91233
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      5189382..5192000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      4400860..4403478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)