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    Nkx2-2 NK2 homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366214, updated on 23-Aug-2016
    Official Symbol
    Nkx2-2provided by RGD
    Official Full Name
    NK2 homeobox 2provided by RGD
    Primary source
    RGD:1308443
    See related
    Ensembl:ENSRNOG00000012728
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Orthologs
    Location:
    3q41
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (141408460..141419083, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (147826697..147837976, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547081 Neighboring gene NK2 homeobox 4 Neighboring gene adenosylmethionine decarboxylase 1, pseudogene 3 Neighboring gene uncharacterized LOC108350489 Neighboring gene paired box 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter proximal region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    core promoter proximal region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cell development ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract development ISO
    Inferred from Sequence Orthology
    more info
     
    endocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    neuron fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    oligodendrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    optic nerve development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    pancreatic A cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    pancreatic A cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    pancreatic PP cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    pancreatic PP cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord motor neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    spinal cord motor neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord oligodendrocyte cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord oligodendrocyte cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    spinal cord oligodendrocyte cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    type B pancreatic cell development IEA
    Inferred from Electronic Annotation
    more info
     
    type B pancreatic cell development ISO
    Inferred from Sequence Orthology
    more info
     
    type B pancreatic cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    type B pancreatic cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    ventral spinal cord interneuron fate determination IEA
    Inferred from Electronic Annotation
    more info
     
    ventral spinal cord interneuron fate determination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    homeobox protein Nkx-2.2
    Names
    NK2 transcription factor related, locus 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191904.1NP_001178833.1  homeobox protein Nkx-2.2

      Status: PROVISIONAL

      Source sequence(s)
      AABR07054109
      UniProtKB/TrEMBL
      D3ZDQ2
      Related
      ENSRNOP00000017364, ENSRNOT00000017364
      Conserved Domains (2) summary
      COG5576
      Location:110217
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:131184
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      141408460..141419083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591951.1XP_017447440.1  

      Conserved Domains (2) summary
      COG5576
      Location:110217
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:131184
      Homeobox; Homeobox domain

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      133482823..133485195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)