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    Syne1 spectrin repeat containing nuclear envelope protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499010, updated on 17-Sep-2016
    Symbol
    Syne1provided by RGD
    Full Name
    spectrin repeat containing nuclear envelope protein 1provided by RGD
    Primary source
    RGD:620546
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CPG2; Myne-1
    Summary
    plasticity-related gene; upregulated incortex in response to light type II integral membrane protein localized in the nuclear membrane [RGD} [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1p11
    Exon count:
    116
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (41844840..42086662, complement) , (41608287..41763591, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (42947742..43158478, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 170 Neighboring gene estrogen receptor 1 Neighboring gene nesprin-1-like Neighboring gene uncharacterized LOC102546605 Neighboring gene myc target 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cytoskeletal anchoring at nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of nucleus localization ISO
    Inferred from Sequence Orthology
    more info
     
    muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix anchoring at nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    LINC complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sarcomere ISO
    Inferred from Sequence Orthology
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    nesprin-1
    Names
    nesprin-1-like
    spectrin repeat containing, nuclear envelope 1

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      41608287..41763591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      41844840..42086662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008758713.2XP_008756935.1  

      Conserved Domains (4) summary
      cd00176
      Location:22272437
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:161967
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:29873043
      KASH; Nuclear envelope localization domain
      cl02488
      Location:13881576
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. XM_006227852.3XP_006227914.1  

      Conserved Domains (2) summary
      cd00176
      Location:155365
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:892948
      KASH; Nuclear envelope localization domain
    3. XM_006227851.3XP_006227913.1  

      Conserved Domains (4) summary
      COG1196
      Location:219965
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:22222432
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:29593015
      KASH; Nuclear envelope localization domain
      cl02488
      Location:186409
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      37192707..37662090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008774326.2XP_008772548.1  

      Conserved Domains (8) summary
      COG0419
      Location:45165131
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:60026748
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:28141
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:80058215
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00307
      Location:187285
      CH; Calponin homology (CH) domain
      pfam10541
      Location:87658821
      KASH; Nuclear envelope localization domain
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001029909.1: Suppressed sequence

      Description
      NM_001029909.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: SYNE1 (GeneID:23345).
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