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Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 11438, updated on 6-Jul-2014
Official Symbol
Chrna4provided by MGI
Official Full Name
cholinergic receptor, nicotinic, alpha polypeptide 4provided by MGI
Primary source
MGI:87888
See related
Ensembl:ENSMUSG00000027577; Vega:OTTMUSG00000016395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EBN1; Acra4; ENFL1; Acra-4
See Chrna4 in Epigenomics, MapViewer
Location:
2 H4; 2 103.54 cM
Exon count :
7
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (181022311..181043577, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor GTPase activating protein 1 Neighboring gene collagen, type XX, alpha 1 Neighboring gene uncharacterized LOC102632823 Neighboring gene potassium voltage-gated channel, subfamily Q, member 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acetylcholine binding ISO
Inferred from Sequence Orthology
more info
 
acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
acetylcholine-activated cation-selective channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acetylcholine-activated cation-selective channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acetylcholine-activated cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
 
acetylcholine-activated cation-selective channel activity TAS
Traceable Author Statement
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
extracellular ligand-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation transport ISO
Inferred from Sequence Orthology
more info
 
cognition ISO
Inferred from Sequence Orthology
more info
 
exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane depolarization IGI
Inferred from Genetic Interaction
more info
PubMed 
membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurological system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurological system process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inhibitory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
respiratory gaseous exchange IMP
Inferred from Mutant Phenotype
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to nicotine IGI
Inferred from Genetic Interaction
more info
PubMed 
response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of pain TAS
Traceable Author Statement
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, cholinergic IDA
Inferred from Direct Assay
more info
PubMed 
synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine-gated channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
neuronal acetylcholine receptor subunit alpha-4
Names
neuronal acetylcholine receptor subunit alpha-4
alpha4 nAChR
alpha4-nAChR
a4 nicotinic receptor
acetylcholine receptor alpha 4 neural
acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015730.5NP_056545.3  neuronal acetylcholine receptor subunit alpha-4 precursor

    See proteins identical to NP_056545.3

    Status: VALIDATED

    Source sequence(s)
    AL450341, BC053013
    Consensus CDS
    CCDS17192.1
    UniProtKB/Swiss-Prot
    O70174
    UniProtKB/TrEMBL
    Q53YK0
    Related
    ENSMUSP00000066338, OTTMUSP00000017643, ENSMUST00000067120, OTTMUST00000039488
    Conserved Domains (2) summary
    pfam02931
    Location:39245
    Blast Score: 822
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:252620
    Blast Score: 559
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    181022311..181043577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500551.1XP_006500614.1  

    Conserved Domains (2) summary
    pfam02931
    Location:22228
    Blast Score: 821
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:235603
    Blast Score: 558
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    185108778..185125645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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