Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Oprm1 opioid receptor, mu 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25601, updated on 20-Aug-2016
    Official Symbol
    Oprm1provided by RGD
    Official Full Name
    opioid receptor, mu 1provided by RGD
    Primary source
    RGD:3234
    See related
    Ensembl:ENSRNOG00000018191 Vega:OTTRNOG00000001849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MORA; Oprm; Oprrm1
    Summary
    receptor that binds morphine with high affinity [RGD, Feb 2006]
    Orthologs
    Location:
    1p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (43454803..43704948)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (44804181..45034145)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene similar to ribosomal protein L13A Neighboring gene uncharacterized LOC102546790 Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene viral oncogene yes homolog Neighboring gene similar to LIM and senescent cell antigen-like domains 1 Neighboring gene Cnksr family member 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    G-protein beta-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G-protein coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-endorphin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    beta-endorphin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    beta-endorphin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    filamin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    morphine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    opioid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acute inflammatory response to antigenic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    adenylate cyclase-activating dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-activating dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-inhibiting opioid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    behavioral response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    estrous cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    excitatory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt protein secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    opioid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    opioid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase C-activating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of appetite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of N-methyl-D-aspartate selective glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cocaine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to food IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to morphine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    mu-type opioid receptor
    Names
    M-OR-1
    MOR-1
    MUOR1
    mu opioid receptor splice variant rMOR-1S
    mu opioid receptor splice variant rMOR-1Z
    opioid receptor B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038597.2NP_001033686.1  mu-type opioid receptor isoform IA

      See identical proteins and their annotated locations for NP_001033686.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1A) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant MOR-1C2. This results in a novel 3' coding region and 3' UTR, compared to variant MOR-1B2. It encodes isoform 1A which is longer/shorter and has a distinct C-terminus, compared to isoform 1C2.
      Source sequence(s)
      AY309000, L13069
      UniProtKB/Swiss-Prot
      P33535
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    2. NM_001038599.2NP_001033688.2  mu-type opioid receptor isoform 1B2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1B2) lacks several exons and contains an alternate terminal exon compared to variant MOR-1C2. The encoded isoform (1B2) is shorter than isoform 1C2.
      Source sequence(s)
      AABR07001431, AABR07001432
      UniProtKB/Swiss-Prot
      P33535
      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    3. NM_001038600.2NP_001033689.1  mu-type opioid receptor isoform 1C1

      See identical proteins and their annotated locations for NP_001033689.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1C1) lacks an alternate segment in the 3' region, compared to variant MOR-1C2. It encodes isoform 1C1 which has is shorter than isoform 1C2.
      Source sequence(s)
      AY225402, L13069
      UniProtKB/Swiss-Prot
      P33535
      Related
      ENSRNOP00000024682, OTTRNOP00000001784, ENSRNOT00000024682, OTTRNOT00000003024
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    4. NM_001038601.2NP_001033690.1  mu-type opioid receptor isoform 1C2

      See identical proteins and their annotated locations for NP_001033690.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1C2) encodes the longest isoform (1C2).
      Source sequence(s)
      AY225403, L13069
      UniProtKB/Swiss-Prot
      P33535
      Related
      ENSRNOP00000068988, OTTRNOP00000001783, ENSRNOT00000092034, OTTRNOT00000003023
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    5. NM_001304733.1NP_001291662.1  mu-type opioid receptor isoform 1G1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1G1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1G1) is shorter than isoform 1C2.
      Source sequence(s)
      AABR07001431, AABR07001432
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    6. NM_001304734.1NP_001291663.1  mu-type opioid receptor isoform 1G2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1G2) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1G2) is shorter than isoform 1C2.
      Source sequence(s)
      AABR07001431, AABR07001432
      Conserved Domains (2) summary
      pfam00001
      Location:7248
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:9193
      7tm_4; Olfactory receptor
    7. NM_001304735.1NP_001291664.1  mu-type opioid receptor isoform 1

      See identical proteins and their annotated locations for NP_001291664.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1H1) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1) is shorter than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3 encode the same isoform.
      Source sequence(s)
      AABR07001431, AABR07001432
      UniProtKB/Swiss-Prot
      P33535
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    8. NM_001304736.1NP_001291665.1  mu-type opioid receptor isoform 1H2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1H2) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1H2) is shorter than isoform 1C2.
      Source sequence(s)
      AABR07001431, AABR07001432
      Conserved Domains (2) summary
      pfam00001
      Location:141386
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:127331
      7tm_4; Olfactory receptor
    9. NM_001304737.1NP_001291666.1  mu-type opioid receptor isoform 1

      See identical proteins and their annotated locations for NP_001291666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1i1) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1) is shorter than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3 encode the same isoform.
      Source sequence(s)
      AABR07001431, AABR07001432
      UniProtKB/Swiss-Prot
      P33535
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    10. NM_001304738.1NP_001291667.1  mu-type opioid receptor isoform 1

      See identical proteins and their annotated locations for NP_001291667.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1i2) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1) is shorter than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3 encode the same isoform.
      Source sequence(s)
      AABR07001431, AABR07001432
      UniProtKB/Swiss-Prot
      P33535
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    11. NM_001304740.1NP_001291669.1  mu-type opioid receptor isoform 1

      See identical proteins and their annotated locations for NP_001291669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1i3) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1) is shorter than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3 encode the same isoform.
      Source sequence(s)
      AABR07001431, AABR07001432
      UniProtKB/Swiss-Prot
      P33535
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    12. NM_013071.2NP_037203.1  mu-type opioid receptor isoform 1

      See identical proteins and their annotated locations for NP_037203.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks several exons and contains an alternate terminal exon compared to variant MOR-1C2. The encoded isoform (1) is shorter than isoform 1C2.
      Source sequence(s)
      L13069, L20684
      UniProtKB/Swiss-Prot
      P33535
      Related
      ENSRNOP00000074079, OTTRNOP00000001786, ENSRNOT00000083308, OTTRNOT00000003026
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor

    RNA

    1. NR_027877.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MOR-1D) uses an alternate 3' exon structure, compared to variant MOR-1C2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY225402, AY309002, L13069
      Related
      ENSRNOT00000079628, OTTRNOT00000003025

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      43454803..43704948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008758731.2XP_008756953.1  

      See identical proteins and their annotated locations for XP_008756953.1

      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    2. XM_017588827.1XP_017444316.1  

      Related
      ENSRNOP00000051290, OTTRNOP00000001787, ENSRNOT00000051837, OTTRNOT00000003021

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      38804246..39057359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)