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    Trpm4 transient receptor potential cation channel, subfamily M, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171143, updated on 26-May-2016
    Official Symbol
    Trpm4provided by RGD
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 4provided by RGD
    Primary source
    RGD:620244
    See related
    Ensembl:ENSRNOG00000020714
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mls2s; LTrpC-4
    Summary
    member of a family of calcium permeable channels [RGD, Feb 2006]
    Orthologs
    Location:
    1q22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101293300..101323187, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (102357043..102387010, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 6, member 16 Neighboring gene similar to Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (Solute carrier family 6 member 16) Neighboring gene PTPRF interacting protein alpha 3 Neighboring gene histidine rich calcium binding protein Neighboring gene chromosome 1 open reading frame, human C19orf73

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of atrial cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of regulation of vascular smooth muscle cell membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of T cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    transient receptor potential cation channel subfamily M member 4
    Names
    LTrpC4
    calcium-activated non-selective cation channel 1
    long transient receptor potential channel 4
    melastatin like 2 protein
    melastatin-like 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136229.1NP_001129701.1  transient receptor potential cation channel subfamily M member 4

      See identical proteins and their annotated locations for NP_001129701.1

      Status: PROVISIONAL

      Source sequence(s)
      AC095435
      UniProtKB/Swiss-Prot
      Q9ESQ5
      Related
      ENSRNOP00000041387, ENSRNOT00000041513
      Conserved Domains (1) summary
      pfam00520
      Location:856923
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      101293300..101323187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      90039848..90063911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133607.1: Suppressed sequence

      Description
      NM_133607.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.