Display Settings:

Format

Send to:

Choose Destination

Cnr1 cannabinoid receptor 1 (brain) [ Rattus norvegicus (Norway rat) ]

Gene ID: 25248, updated on 8-Dec-2014
Official Symbol
Cnr1provided by RGD
Official Full Name
cannabinoid receptor 1 (brain)provided by RGD
Primary source
RGD:2369
See related
Ensembl:ENSRNOG00000008223
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
SKR6R
Summary
G-protein coupled receptor for psychoactive cannabinoids; may mediate inhibition of NO production and participate in retrograde signaling by endocannabinoids [RGD, Feb 2006]
See Cnr1 in MapViewer
Location:
5q21
Exon count:
3
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (49309324..49333064)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (53878619..53904013)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556373 Neighboring gene similar to BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2 isoform beta Neighboring gene uncharacterized LOC103692331 Neighboring gene sperm acrosome associated 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cannabinoid receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cannabinoid receptor activity ISO
Inferred from Sequence Orthology
more info
 
drug binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
cannabinoid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cannabinoid signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cannabinoid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
memory IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ion transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of acute inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fever generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of penile erection IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Colocalizes_with intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cannabinoid receptor 1
Names
cannabinoid receptor 1
CB1
CB-R
brain-type cannabinoid receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012784.4NP_036916.1  cannabinoid receptor 1

    See proteins identical to NP_036916.1

    Status: PROVISIONAL

    Source sequence(s)
    X55812
    UniProtKB/Swiss-Prot
    P20272
    Related
    ENSRNOP00000010850, ENSRNOT00000010850
    Conserved Domains (2) summary
    pfam00001
    Location:140398
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:135413
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 

    Range
    49309324..49333064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237984.2XP_006238046.1  

    See proteins identical to XP_006238046.1

    UniProtKB/Swiss-Prot
    P20272
    Conserved Domains (2) summary
    pfam00001
    Location:140398
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:135413
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

Alternate Rn_Celera

Genomic

  1. AC_000073.1 

    Range
    47168709..47190724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)