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    GLTP glycolipid transfer protein [ Homo sapiens (human) ]

    Gene ID: 51228, updated on 14-Apr-2016
    Official Symbol
    GLTPprovided by HGNC
    Official Full Name
    glycolipid transfer proteinprovided by HGNC
    Primary source
    HGNC:HGNC:24867
    See related
    Ensembl:ENSG00000139433 HPRD:16409; MIM:608949; Vega:OTTHUMG00000169278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    12q24.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (109850943..109880488, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110288748..110318293, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily V member 4 Neighboring gene uncharacterized LOC105369975 Neighboring gene microRNA 4497 Neighboring gene trichoplein keratin filament binding Neighboring gene GIT ArfGAP 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of the metabolic syndrome in Indian Asian men.
    NHGRI GWA Catalog
    • Glycosphingolipid metabolism, organism-specific biosystem (from REACTOME)
      Glycosphingolipid metabolism, organism-specific biosystemThe steps involved in the synthesis of glycosphingolipids (sphingolipids with one or more sugars attached) are annotated here (Gault et al. 2010).
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Sphingolipid metabolism, organism-specific biosystem (from REACTOME)
      Sphingolipid metabolism, organism-specific biosystemSphingolipids are derivatives of long chain sphingoid bases such as sphingosine (trans-1,3-dihydroxy 2-amino-4-octadecene), an 18-carbon unsaturated amino alcohol which is the most abundant sphingoid...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glycolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycolipid transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycolipid transporter activity TAS
    Traceable Author Statement
    more info
     
    lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    glycolipid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycosphingolipid metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IC
    Inferred by Curator
    more info
    PubMed 
    Preferred Names
    glycolipid transfer protein
    Names
    truncated glycolipid transfer protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016433.3NP_057517.1  glycolipid transfer protein

      See identical proteins and their annotated locations for NP_057517.1

      Status: REVIEWED

      Source sequence(s)
      AF209704, AY372530, BC009932, BQ227117, CA310913
      Consensus CDS
      CCDS9136.1
      UniProtKB/Swiss-Prot
      Q9NZD2
      UniProtKB/TrEMBL
      A0A024RBI7
      Related
      ENSP00000315263, OTTHUMP00000240666, ENST00000318348, OTTHUMT00000403278
      Conserved Domains (1) summary
      pfam08718
      Location:16169
      GLTP; Glycolipid transfer protein (GLTP)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

      Range
      109850943..109880488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538434.1XP_011536736.1  

      See identical proteins and their annotated locations for XP_011536736.1

      Conserved Domains (1) summary
      pfam08718
      Location:13128
      GLTP; Glycolipid transfer protein (GLTP)

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      110256554..110286100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)