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NEIL1 nei endonuclease VIII-like 1 (E. coli) [ Homo sapiens (human) ]

Gene ID: 79661, updated on 7-Dec-2014
Official Symbol
NEIL1provided by HGNC
Official Full Name
nei endonuclease VIII-like 1 (E. coli)provided by HGNC
Primary source
HGNC:HGNC:18448
See related
Ensembl:ENSG00000140398; HPRD:12314; MIM:608844; Vega:OTTHUMG00000142821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPG1; NEI1; hFPG1
Summary
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
See NEIL1 in Epigenomics, MapViewer
Location:
15q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (75346990..75355251)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75639331..75647592)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 1 Neighboring gene COMM domain containing 4 Neighboring gene microRNA 631 Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene SIN3 transcription regulator family member A Neighboring gene ribosomal protein L13 pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Base excision repair, organism-specific biosystem (from KEGG)
    Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • Base excision repair, conserved biosystem (from KEGG)
    Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22402

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-(apurinic or apyrimidinic site) lyase activity IEA
Inferred from Electronic Annotation
more info
 
damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on glycosyl bonds IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA catabolic process, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
endonuclease 8-like 1
Names
endonuclease 8-like 1
NEH1
nei homolog 1
endonuclease VIII
nei-like protein 1
endonuclease VIII-like 1
DNA glycosylase/AP lyase Neil1
DNA-(apurinic or apyrimidinic site) lyase Neil1
NP_001243481.1
NP_078884.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256552.1NP_001243481.1  endonuclease 8-like 1 isoform 1

    See proteins identical to NP_001243481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC068338, BC010876
    UniProtKB/Swiss-Prot
    Q96FI4
    Related
    ENSP00000455730, OTTHUMP00000249070, ENST00000569035, OTTHUMT00000419886
    Conserved Domains (3) summary
    pfam06831
    Location:220283
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:338376
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:87213
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
  2. NM_024608.3NP_078884.2  endonuclease 8-like 1 isoform 2

    See proteins identical to NP_078884.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB079068, AC068338, AK026055, DB282730
    Consensus CDS
    CCDS10278.1
    UniProtKB/Swiss-Prot
    Q96FI4
    Conserved Domains (3) summary
    pfam06831
    Location:134197
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:252290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:1127
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)

RNA

  1. NR_046311.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068338, AK097008

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    75346990..75355251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720681.1XP_006720744.1  

    See proteins identical to XP_006720744.1

    UniProtKB/Swiss-Prot
    Q96FI4
    Conserved Domains (3) summary
    pfam06831
    Location:134197
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:252290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:1127
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
  2. XM_006720678.1XP_006720741.1  

    Conserved Domains (2) summary
    pfam09292
    Location:298336
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:87213
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
  3. XM_006720677.1XP_006720740.1  

    Conserved Domains (3) summary
    pfam06831
    Location:211274
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:329367
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:78204
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
  4. XM_006720680.1XP_006720743.1  

    See proteins identical to XP_006720743.1

    UniProtKB/Swiss-Prot
    Q96FI4
    Conserved Domains (3) summary
    pfam06831
    Location:134197
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:252290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:1127
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
  5. XM_006720682.1XP_006720745.1  

    See proteins identical to XP_006720745.1

    UniProtKB/Swiss-Prot
    Q96FI4
    Conserved Domains (3) summary
    pfam06831
    Location:134197
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:252290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:1127
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
  6. XM_006720679.1XP_006720742.1  

    See proteins identical to XP_006720742.1

    Conserved Domains (3) summary
    pfam06831
    Location:177240
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:295333
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:44170
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)
  7. XM_005254659.2XP_005254716.1  

    See proteins identical to XP_005254716.1

    UniProtKB/Swiss-Prot
    Q96FI4
    Conserved Domains (3) summary
    pfam06831
    Location:134197
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain
    pfam09292
    Location:252290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cd08967
    Location:1127
    MeNeil1_N; N-terminal domain of metazoan Nei-like glycosylase 1 (NEIL1)

RNA

  1. XR_243127.2 RNA Sequence

  2. XR_429472.1 RNA Sequence

  3. XR_429471.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    75757932..75766193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    52397780..52405946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)