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Scn3a sodium channel, voltage-gated, type III, alpha subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 497770, updated on 6-May-2015
Official Symbol
Scn3aprovided by RGD
Official Full Name
sodium channel, voltage-gated, type III, alpha subunitprovided by RGD
Primary source
RGD:3635
See related
Ensembl:ENSRNOG00000005007
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
SCIII; Scn2a; Nav1.3
Summary
may play a role in neuronal hyperexcitability and neuropathic pain in response to spinal cord injury [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Orthologs
See Scn3a in MapViewer
Location:
3q21
Exon count:
30
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (51530897..51643140, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (58165763..58277870, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene cordon-bleu WH2 repeat protein-like 1 Neighboring gene solute carrier family 38, member 11 Neighboring gene uncharacterized LOC102553383 Neighboring gene sodium channel, voltage-gated, type II, alpha subunit Neighboring gene cysteine-serine-rich nuclear protein 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated sodium channel activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to antibiotic IDA
Inferred from Direct Assay
more info
PubMed 
membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
neuronal action potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
response to pyrethroid IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
voltage-gated sodium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 
voltage-gated sodium channel complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
sodium channel protein type 3 subunit alpha
Names
sodium channel protein type 3 subunit alpha
sodium channel protein brain III subunit alpha
sodium channel protein type III subunit alpha
sodium channel protein, brain III subunit alpha
sodium channel, voltage-gated, type 3, alpha subunit
voltage-gated sodium channel subtype III
voltage-gated sodium channel subunit alpha Nav1.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013119.1NP_037251.1  sodium channel protein type 3 subunit alpha

    See identical proteins and their annotated locations for NP_037251.1

    Status: PROVISIONAL

    Source sequence(s)
    Y00766
    UniProtKB/Swiss-Prot
    P08104
    Related
    ENSRNOP00000006646, ENSRNOT00000006646
    Conserved Domains (5) summary
    cd13433
    Location:14201472
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:11931418
    Ion_trans; Ion transport protein
    pfam06512
    Location:9491167
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:496662
    DUF3451; Domain of unknown function (DUF3451)
    cl16916
    Location:16591694
    ChtBD1; Hevein or type 1 chitin binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    51530897..51643140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761915.1XP_008760137.1  

    See identical proteins and their annotated locations for XP_008760137.1

    Conserved Domains (5) summary
    cd13433
    Location:14521504
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:12251450
    Ion_trans; Ion transport protein
    pfam06512
    Location:9811199
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:496694
    DUF3451; Domain of unknown function (DUF3451)
    cl16916
    Location:16911726
    ChtBD1; Hevein or type 1 chitin binding domain
  2. XM_008761916.1XP_008760138.1  

    Conserved Domains (5) summary
    cd13433
    Location:14521504
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:12251450
    Ion_trans; Ion transport protein
    pfam06512
    Location:9811199
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:496694
    DUF3451; Domain of unknown function (DUF3451)
    cl16916
    Location:16911726
    ChtBD1; Hevein or type 1 chitin binding domain
  3. XM_008761919.1XP_008760141.1  

    Conserved Domains (5) summary
    cd13433
    Location:14201472
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:11931418
    Ion_trans; Ion transport protein
    pfam06512
    Location:9491167
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:496662
    DUF3451; Domain of unknown function (DUF3451)
    cl16916
    Location:16591694
    ChtBD1; Hevein or type 1 chitin binding domain
  4. XM_008761918.1XP_008760140.1  

    Conserved Domains (5) summary
    cd13433
    Location:14231475
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:11961421
    Ion_trans; Ion transport protein
    pfam06512
    Location:9521170
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:496665
    DUF3451; Domain of unknown function (DUF3451)
    cl16916
    Location:16621697
    ChtBD1; Hevein or type 1 chitin binding domain
  5. XM_008761917.1XP_008760139.1  

    See identical proteins and their annotated locations for XP_008760139.1

    Conserved Domains (5) summary
    cd13433
    Location:14521504
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:12251450
    Ion_trans; Ion transport protein
    pfam06512
    Location:9811199
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:496694
    DUF3451; Domain of unknown function (DUF3451)
    cl16916
    Location:16911726
    ChtBD1; Hevein or type 1 chitin binding domain
  6. XM_008761914.1XP_008760136.1  

    See identical proteins and their annotated locations for XP_008760136.1

    Conserved Domains (5) summary
    cd13433
    Location:14521504
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:12251450
    Ion_trans; Ion transport protein
    pfam06512
    Location:9811199
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:496694
    DUF3451; Domain of unknown function (DUF3451)
    cl16916
    Location:16911726
    ChtBD1; Hevein or type 1 chitin binding domain
  7. XM_008761920.1XP_008760142.1  

    Conserved Domains (5) summary
    cd13433
    Location:14201472
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:11931418
    Ion_trans; Ion transport protein
    pfam06512
    Location:9491167
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:496662
    DUF3451; Domain of unknown function (DUF3451)
    cl16916
    Location:16591694
    ChtBD1; Hevein or type 1 chitin binding domain

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    49742093..49851946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)