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    Egf epidermal growth factor [ Mus musculus (house mouse) ]

    Gene ID: 13645, updated on 24-Sep-2016
    Official Symbol
    Egfprovided by MGI
    Official Full Name
    epidermal growth factorprovided by MGI
    Primary source
    MGI:MGI:95290
    See related
    Ensembl:ENSMUSG00000028017 Vega:OTTMUSG00000054128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI790464
    Summary
    This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]
    Orthologs
    Location:
    3 G3; 3 58.5 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (129677574..129755439, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (129380493..129458240, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 7 Neighboring gene predicted gene, 35986 Neighboring gene ELOVL family member 6, elongation of long chain fatty acids (yeast) Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene predicted gene, 36130 Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene retinal pigment epithelium derived rhodopsin homolog

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Wnt-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    epidermal growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    STAT protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway involved in dorsal/ventral axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    branching morphogenesis of an epithelial tube IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland alveolus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catenin import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cerebellar granule cell precursor proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    pro-epidermal growth factor
    Names
    Pro-epidermal growth factor precursor (EGF)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310737.1NP_001297666.1  pro-epidermal growth factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC098732, AK136439, AK157778, BP761200
      Consensus CDS
      CCDS80020.1
      UniProtKB/TrEMBL
      A0A0G2JF92, Q3UWD7
      Related
      ENSMUSP00000143075, OTTMUSP00000071665, ENSMUST00000197079, OTTMUST00000135432
      Conserved Domains (5) summary
      PHA02887
      Location:481518
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:95138
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07001
      Location:609700
      BAT2_N; BAT2 N-terminus
      pfam07645
      Location:376416
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:250285
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. NM_001329594.1NP_001316523.1  pro-epidermal growth factor isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC098732, AK085707, BB635280, BP761200
    3. NM_010113.4NP_034243.2  pro-epidermal growth factor isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_034243.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC098732, AK136439, BP761200
      Consensus CDS
      CCDS17833.1
      UniProtKB/Swiss-Prot
      P01132
      UniProtKB/TrEMBL
      Q3UWD7
      Related
      ENSMUSP00000029653, OTTMUSP00000071300, ENSMUST00000029653, OTTMUST00000134475
      Conserved Domains (5) summary
      PHA02887
      Location:9821019
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:596639
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07645
      Location:877917
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:449482
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:358399
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      129677574..129755439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240011.2XP_011238313.1  

      Conserved Domains (4) summary
      PHA02887
      Location:945982
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:600643
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07645
      Location:881921
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:370405
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. XM_011240010.2XP_011238312.1  

      Conserved Domains (5) summary
      PHA02887
      Location:9861023
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:600643
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07645
      Location:881921
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:453486
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:362403
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    3. XM_006500990.3XP_006501053.1  

      Conserved Domains (4) summary
      PHA02887
      Location:941978
      PHA02887; EGF-like protein; Provisional
      smart00135
      Location:596639
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam07645
      Location:877917
      EGF_CA; Calcium-binding EGF domain
      pfam14670
      Location:366401
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RNA

    1. XR_001783650.1 RNA Sequence

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