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Adipoq adiponectin, C1Q and collagen domain containing [ Mus musculus (house mouse) ]

Gene ID: 11450, updated on 23-Dec-2014
Official Symbol
Adipoqprovided by MGI
Official Full Name
adiponectin, C1Q and collagen domain containingprovided by MGI
Primary source
MGI:MGI:106675
See related
Ensembl:ENSMUSG00000022878; Vega:OTTMUSG00000035780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APN; Acdc; apM1; 30kDa; GBP28; adipo; Acrp30
See Adipoq in Epigenomics, MapViewer
Location:
16 B3-B4; 16 13.96 cM
Exon count:
3
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 16 NC_000082.6 (23146536..23157968)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene replication factor C (activator 1) 4 Neighboring gene predicted pseudogene 6630 Neighboring gene lactate dehydrogenase A pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Leptin and adiponectin, organism-specific biosystem (from WikiPathways)
    Leptin and adiponectin, organism-specific biosystemProposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem (from LIPID MAPS)
    PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem
    PPAR (Peroxisome proliferator-activated receptor) signaling pathway
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, organism-specific biosystem (from WikiPathways)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, conserved biosystem (from KEGG)
    Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
hormone activity ISO
Inferred from Sequence Orthology
more info
 
hormone activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
sialic acid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adiponectin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
detection of oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of low-density lipoprotein particle receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of metanephric mesenchymal cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose import IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glycogen (starch) synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric glomerular visceral epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of renal albumin absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of renal albumin absorption ISO
Inferred from Sequence Orthology
more info
 
positive regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
protein heterotrimerization IPI
Inferred from Physical Interaction
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
adiponectin
Names
adiponectin
adipocyte-specific protein AdipoQ
adipocyte complement related protein
30 kDa adipocyte complement-related protein
adipocyte complement-related 30 kDa protein
adipocyte, C1Q and collagen domain containing
adipocyte, C1q and collagen domain-containing protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009605.4NP_033735.3  adiponectin precursor

    See proteins identical to NP_033735.3

    Status: VALIDATED

    Source sequence(s)
    AK134112
    Consensus CDS
    CCDS28075.1
    UniProtKB/Swiss-Prot
    Q60994
    Related
    ENSMUSP00000023593, OTTMUSP00000050447, ENSMUST00000023593, OTTMUST00000091562
    Conserved Domains (2) summary
    smart00110
    Location:112245
    C1Q; Complement component C1q domain
    pfam01391
    Location:45107
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000082.6 

    Range
    23146536..23157968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000038.1 

    Range
    23704853..23716285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)