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Bmpr1a bone morphogenetic protein receptor, type 1A [ Mus musculus (house mouse) ]

Gene ID: 12166, updated on 13-Aug-2014
Official Symbol
Bmpr1aprovided by MGI
Official Full Name
bone morphogenetic protein receptor, type 1Aprovided by MGI
Primary source
MGI:1338938
See related
Ensembl:ENSMUSG00000021796; Vega:OTTMUSG00000036087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALK3; Bmpr; BMPR-IA; AU045487; 1110037I22Rik
See Bmpr1a in Epigenomics, MapViewer
Location:
14 B; 14 20.81 cM
Exon count:
14
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (34411061..34503529, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene synuclein, gamma Neighboring gene multimerin 2 Neighboring gene RIKEN cDNA 9230112D13 gene Neighboring gene 60S ribosomal protein L21-like Neighboring gene LIM domain binding 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
    Endochondral Ossification, organism-specific biosystem
    Endochondral Ossification
  • Heart Development, organism-specific biosystem (from WikiPathways)
    Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
    PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by BMP, organism-specific biosystem (from REACTOME)
    Signaling by BMP, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor signaling protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding RNA polymerase II transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Mullerian duct regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
ectoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
 
embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lateral mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesendoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural plate mediolateral regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural plate pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
paraxial mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
paraxial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
paraxial mesoderm structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular senescence IGI
Inferred from Genetic Interaction
more info
 
NOT regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
 
NOT regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
 
regulation of lateral mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
bone morphogenetic protein receptor type-1A
Names
bone morphogenetic protein receptor type-1A
SKR5
ALK-3
BMPR-1A
BMP type-1A receptor
BMP-2/BMP-4 receptor
activin receptor-like kinase 3
serine/threonine-protein kinase receptor R5
NP_033888.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009758.4NP_033888.2  bone morphogenetic protein receptor type-1A precursor

    See proteins identical to NP_033888.2

    Status: VALIDATED

    Source sequence(s)
    AC160930, AC166105
    Consensus CDS
    CCDS26938.1
    UniProtKB/Swiss-Prot
    P36895
    UniProtKB/TrEMBL
    Q53Z43
    Related
    ENSMUSP00000035900, OTTMUSP00000051312, ENSMUST00000049005, OTTMUST00000092723
    Conserved Domains (3) summary
    cd00180
    Location:240440
    Blast Score: 358
    PKc; Catalytic domain of Protein Kinases
    pfam00069
    Location:237519
    Blast Score: 511
    Pkinase; Protein kinase domain
    pfam01064
    Location:59138
    Blast Score: 175
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    34411061..34503529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518470.1XP_006518533.1  

    See proteins identical to XP_006518533.1

    UniProtKB/Swiss-Prot
    P36895
    UniProtKB/TrEMBL
    Q53Z43
    Conserved Domains (3) summary
    cd00180
    Location:240440
    Blast Score: 358
    PKc; Catalytic domain of Protein Kinases
    pfam00069
    Location:237519
    Blast Score: 511
    Pkinase; Protein kinase domain
    pfam01064
    Location:59138
    Blast Score: 175
    Activin_recp; Activin types I and II receptor domain
  2. XM_006518469.1XP_006518532.1  

    See proteins identical to XP_006518532.1

    UniProtKB/Swiss-Prot
    P36895
    UniProtKB/TrEMBL
    Q53Z43
    Conserved Domains (3) summary
    cd00180
    Location:240440
    Blast Score: 358
    PKc; Catalytic domain of Protein Kinases
    pfam00069
    Location:237519
    Blast Score: 511
    Pkinase; Protein kinase domain
    pfam01064
    Location:59138
    Blast Score: 175
    Activin_recp; Activin types I and II receptor domain

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    30676409..30725958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)