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    Il4ra interleukin 4 receptor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 16190, updated on 26-Jun-2015
    Official Symbol
    Il4raprovided by MGI
    Official Full Name
    interleukin 4 receptor, alphaprovided by MGI
    Primary source
    MGI:MGI:105367
    See related
    Ensembl:ENSMUSG00000030748
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il4r; CD124
    Orthologs
    See Il4ra in Epigenomics, MapViewer
    Location:
    7 F3; 7 68.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (125552282..125579474)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (132695796..132722988)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene non-SMC element 1 homolog (S. cerevisiae) Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene Neighboring gene interleukin 21 receptor Neighboring gene general transcription factor III C 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 signaling Pathway, organism-specific biosystem
      IL-4 signaling Pathway
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC118473

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    interleukin-4 receptor subunit alpha
    Names
    interleukin-4 receptor subunit alpha
    IL-4 receptor alpha chain
    IL-4 receptor subunit alpha
    IL-4R subunit alpha
    IL-4R-alpha
    IL-4RA

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008700.3NP_001008700.1  interleukin-4 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_001008700.1

      Status: PROVISIONAL

      Source sequence(s)
      BC112911
      Consensus CDS
      CCDS40121.1
      UniProtKB/Swiss-Prot
      P16382
      UniProtKB/TrEMBL
      Q3U905
      Related
      ENSMUSP00000033004, ENSMUST00000033004
      Conserved Domains (2) summary
      pfam09238
      Location:27122
      IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
      cd00063
      Location:124221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      125552282..125579474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507388.1XP_006507451.1  

      Conserved Domains (1) summary
      PHA03247
      Location:211475
      PHA03247; large tegument protein UL36; Provisional

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      125410962..125438138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010557.1: Suppressed sequence

      Description
      NM_010557.1: This RefSeq was permanently suppressed because it is an NMD candidate.