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Zfp36 zinc finger protein 36 [ Mus musculus (house mouse) ]

Gene ID: 22695, updated on 7-Apr-2015
Official Symbol
Zfp36provided by MGI
Official Full Name
zinc finger protein 36provided by MGI
Primary source
MGI:MGI:99180
See related
Ensembl:ENSMUSG00000044786; Vega:OTTMUSG00000021115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttp; Gos24; TISII; Tis11; Nup475; TIS11D; Zfp-36
Orthologs
See Zfp36 in MapViewer
Location:
7 A3; 7 16.72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (28376784..28379228, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29161803..29164247, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2 Neighboring gene nuclear encoded tRNA isoleucine 16 (anticodon TAT) Neighboring gene mediator complex subunit 29 Neighboring gene Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
AU-rich element binding IDA
Inferred from Direct Assay
more info
PubMed 
AU-rich element binding ISO
Inferred from Sequence Orthology
more info
 
C-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
RNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translation involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
response to starvation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tristetraprolin
Names
tristetraprolin
TPA-induced sequence 11
growth factor-inducible nuclear protein NUP475
tristetraproline

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011756.4NP_035886.1  tristetraprolin

    See proteins identical to NP_035886.1

    Status: PROVISIONAL

    Source sequence(s)
    AC149606
    Consensus CDS
    CCDS21041.1
    UniProtKB/Swiss-Prot
    P22893
    UniProtKB/TrEMBL
    Q3U3D2
    Related
    ENSMUSP00000057815, OTTMUSP00000023255, ENSMUST00000051241, OTTMUST00000049971
    Conserved Domains (1) summary
    pfam00642
    Location:96122
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    28376784..28379228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    22938422..22940866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)